Pursuing Proteomes

Bio-Rad's PROTEAN® IEF System provides 2-D electrophoretic separation as part of the ProteomeWorks System

Australian postdoctoral fellow Marc Wilkins coined the term "proteome" in the mid-'90s, referring to the total set of proteins expressed in a given cell at a given time. The term took hold, and a new scientific discipline was born. In proteomic studies, all the proteins from a given cell, organelle, or tissue are analyzed simultaneously with respect to properties such as expression levels, posttranslational modifications, and interactions with other molecules.¹ Proteomics is a young discipline but is rapidly growing due to the development, integration, and automation of requisite large-scale analytical tools and the emergence of sophisticated bioinformatic techniques. The push is on to obtain global, integrated views of disease states and cellular processes at the proteome level.

Proteome Express

Numerous factors control protein expression patterns, including developmental stage of the organism, environmental influences, and...