Pursuing Proteomes

Bio-Rad's PROTEAN® IEF System provides 2-D electrophoretic separation as part of the ProteomeWorks System Australian postdoctoral fellow Marc Wilkins coined the term "proteome" in the mid-'90s, referring to the total set of proteins expressed in a given cell at a given time. The term took hold, and a new scientific discipline was born. In proteomic studies, all the proteins from a given cell, organelle, or tissue are analyzed simultaneously with respect to properties such as expression leve

Written byDeborah Wilkinson

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Bio-Rad's PROTEAN^® IEF System provides 2-D electrophoretic separation as part of the ProteomeWorks System

Australian postdoctoral fellow Marc Wilkins coined the term "proteome" in the mid-'90s, referring to the total set of proteins expressed in a given cell at a given time. The term took hold, and a new scientific discipline was born. In proteomic studies, all the proteins from a given cell, organelle, or tissue are analyzed simultaneously with respect to properties such as expression levels, posttranslational modifications, and interactions with other molecules.¹ Proteomics is a young discipline but is rapidly growing due to the development, integration, and automation of requisite large-scale analytical tools and the emergence of sophisticated bioinformatic techniques. The push is on to obtain global, integrated views of disease states and cellular processes at the proteome level.

Two-dimensional (2-D) gel electrophoresis is the most widely used tool for separating proteins in expression proteomics. In 2-D gel ...

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