Skip to main content

Scanning Microscopes Bring Imaging To The Atomic Scale

In 1990, scientists at IBM Corp.'s Almaden Research Center in San Jose, Calif., used the minute tungsten probe of a scanning tunneling microscope to move atoms of xenon around on a nickel surface, ultimately spelling out the letters I-B-M (Nature, 344:524-6, 1990). This remarkable feat of engineering opened up an entirely new realm of applications for this microscope, which was designed to image atomic-sized specimens, not push them around. Since the first transmission electron microscope wa

Written byHolly Ahern
| 8 min read

Register for free to listen to this article
Listen with Speechify
0:00
8:00

Since the first transmission electron microscope was sold in 1935, microscopes that use electrons--rather than light waves--to image objects have brought into focus levels of detail that were previously unimaginable. The scanning tunneling microscope (STM) is one of the more recent developments in this field, and using STM to write with atoms is one of its more innovative applications. But scientists are using electron microscopy in other new ways, as well. These include constructing three- dimensional images of minerals and some biological molecules, creating and analyzing polymers and superconductors, and even watching--on the atomic level--complex biological processes in action.

The electron microscope is essentially a light microscope that uses beams of high-energy electrons in place of light waves to illuminate the specimen. Using electrons with wavelengths as small as 0.1 nanometer, rather than longer-wavelength visible light, removes the limits on resolution imposed by diffraction in optical microscopy. The transmission electron ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!
Already a member?
Add The Scientist as a preferred source on Google

Add The Scientist as a preferred Google source to see more of our trusted coverage.

Meet the Author

  • The Scientist Placeholder Image

    Holly Ahern is a science writer and an assistant professor of biology at Adirondack Community College in Queensbury, N.Y.

    View Full Profile

Related Topics

Published In

Related articles background image
The Scientist Digest cover September 2026
September 2026

Multiplex Microscopy Becomes Easier with Encoded Antibodies

A new system that enables researchers to uniquely tag monoclonal antibodies for use in microscopy could help simplify complex imaging studies.

View this Issue
Essential Genes Are Dominantly Activated by Single Transcription Factors

Essential Genes Are Dominantly Activated by Single Transcription Factors

EpiCypher Logo
Rethinking ALS Biomarkers: From Discovery to Clinical Impact

Rethinking ALS Biomarkers: From Discovery to Clinical Impact

Alamar Biosciences logo
Engineering CAR-Neutrophils In Vivo to Target Glioblastoma

Engineering CAR-Neutrophils In Vivo to Target Glioblastoma

Miltenyi
Best Practices for qPCR Assay Design and Optimization

Best Practices for qPCR Assay Design and Optimization

Bio-Rad

Products

Closeup image of a multi channel pipette dispensing pink liquid into a 96-well plate.

The ASSIST PLUS pipetting robot for affordable workflow automation

Integra Logo
Single cells in suspension

Rapidly isolate primary cells and make uniform single-cell suspensions with Corning® Cell Strainers

Corning logo
Abstract image representing cell membranes linked together.

CellBrite® Steady Membrane Stain: Cell surface staining built for real-time imaging

Biotium
sino biological logo

Monod Bio Licenses AI-designed Protein Technologies to SignalChem Biotech for Custom Discovery Assays