Researchers are retracting a highly-cited linkurl:2004 Science paper; describing a new way of adding sugars to proteins -- a longstanding challenge in molecular biology -- citing their inability to repeat the results and the absence of the original lab notebooks with the experiment details, they linkurl:announced; in Science last Thursday (November 26).
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"It is unfortunate that they cannot repeat it," said biochemist linkurl:Lai-Xi Wang; of the University of Maryland School of Medicine, who did not participate in the retracted research. "This method opened a new avenue for the preparation of glycoproteins [with] huge potential in this field." Glycosylation, the addition of sugars to proteins, is a common posttranslational modification that is found on some 70% of human proteins. It can affect a variety of protein functions, including folding and biomolecular recognition, but the exact relationship between the structural and functional changes remains elusive. One of the reasons...
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