D.G. Wang, J.B. Fan, C.J. Siao, A. Berno, P. Young, R. Sapolsky, G. Ghandour, N. Perkins, E. Winchester, J. Spencer, L. Kruglyak, L. Stein, L. Hsie, T. Topaloglou, E. Hubbell, E. Robinson, M. Mittmann, M.S. Morris, N.P. Shen, D. Kilburn, J. Rioux, C. Nusbaum, S. Rozen, T.J. Hudson, R. Lipshutz, M. Chee, E.S. Lander, "Large-scale identification, mapping, and genotyping of single-nucleotide polymorphisms in the human genome," Science, 280:1077-82, 1998. (Cited in more than 205 papers since publication)
It wasn't until recently that researchers realized the potential of SNPs. "We first proposed the idea of creating a comprehensive catalog of all common human genetic variations in a paper in 1995,"1 says Eric S. Lander, professor of biology and director of the Whitehead/Massachusetts Institute of Technology Center for Genome Research. "We realized that the fact that the human population rapidly expanded from a small founding population some 7,000 generations ago in Africa ...
