For this article, Jennifer Fisher Wilson interviewed Eric S. Lander, professor of biology and director of the Whitehead/Massachusetts Institute of Technology Center for Genome Research. Data from the Web of Science (ISI, Philadelphia) show that the Hot Papers are cited 50 to 100 times more often than the average paper of the same type and age.

D.G. Wang, J.B. Fan, C.J. Siao, A. Berno, P. Young, R. Sapolsky, G. Ghandour, N. Perkins, E. Winchester, J. Spencer, L. Kruglyak, L. Stein, L. Hsie, T. Topaloglou, E. Hubbell, E. Robinson, M. Mittmann, M.S. Morris, N.P. Shen, D. Kilburn, J. Rioux, C. Nusbaum, S. Rozen, T.J. Hudson, R. Lipshutz, M. Chee, E.S. Lander, "Large-scale identification, mapping, and genotyping of single-nucleotide polymorphisms in the human genome," Science, 280:1077-82, 1998. (Cited in more than 205 papers since publication)

It wasn't until recently that researchers realized the potential of SNPs. "We first proposed the...

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