© 1997 AAAS
Crystal structure of ATP binding site of FGFR1 in complex with SU5402. Molecular surface representation (bottom) and a backbone representation (top) of the same view showing superposition of SU5042 (green) and ATP (yellow) in complex with the kinase domain of FGFR1. Both surface and backbone representations colored purple represent atoms of the hinge region, light blue for atoms of the nucleotide-binding loop and yellow for atoms of the catalytic loop. (From M. Mohammadi et al.,
Every drug has a story behind it. Here, I condense 25 years of hard work by hundreds of people by focusing on key events and characters that shaped the discovery of SU11248, a new cancer drug. Cancers remain an immense problem, but this story has an affirmative message: Investment in basic research, the mining of that research for promising leads, and the relentless, dedicated development of these leads can ...
