First-Generation Antipsychotic Drugs
By Jonathan Scheff

This table lists selected first-generation antipsychotic drugs. For a table of atypical agents, click here. For a table of the next generation of medications, click here.

Drug Brand name(Manufacturer) Approval date Indications Mechanism Cost per 30-day supply* Contraindications/Adverse reactions Injection availability Other data
Prochlorperazine October 1956 Severe nausea and vomiting; schizophrenia; non-psychotic anxiety D2 receptor blockade N/A Contraindicated for comatose states or in the presence of large doses of CNS depressants, pediatric surgery and children under two years old or under 20 pounds; extrapyramidal symptoms, TD, NMS, cholestatic jaundice, leukopenia, agranulocytosis IM, IV
Perphenazine February 1957 Schizophrenia; severe nausea and vomiting in adults D2 receptor blockade $17.30, (8 mg/day) Contraindicated in the presence of existing blood dyscrasias, bone marrow depression, or liver damage, and for patients who are comatose, greatly obtunded, on large doses of CNS depressants, or with subcortical brain damage;...

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