Synthetic Genetic Evolution

Scientists show that manmade nucleic acids can replicate and evolve, ushering in a new era in synthetic biology.

Written byRuth Williams
| 3 min read

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WIKIMEDIA COMMONS, CHRISTOPH BOCK (MAX PLANCK INSTITUTE FOR INFORMATICS)

Synthetic genetic polymers, broadly referred to as XNAs, can replicate and evolve just like their naturally occurring counterparts, DNA and RNA, according to a new study published today (April 19) in Science. The results of the research have implications not only for the fields of biotechnology and drug design, but also for research into the origins of life—on this planet and beyond.

“It’s a breakthrough,” said Gerald Joyce of The Scripps Research Institute in La Jolla, California, who was not involved in the study—“a beautiful paper in the realm of synthetic biology.”

“It shows that you don’t have to stick with the ribose and deoxyribose backbones of RNA and DNA in order to have transmittable, heritable, and evolvable information,” added Eric Kool of Stanford University, ...

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  • ruth williams

    Ruth is a freelance journalist. Before freelancing, Ruth was a news editor for the Journal of Cell Biology in New York and an assistant editor for Nature Reviews Neuroscience in London. Prior to that, she was a bona fide pipette-wielding, test tube–shaking, lab coat–shirking research scientist. She has a PhD in genetics from King’s College London, and was a postdoc in stem cell biology at Imperial College London. Today she lives and writes in Connecticut.

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