Two cells on a purple background. Two mechanisms of gene silencing are shown in the cell on the left, while a double-strand break in a DNA region is shown in the cell on the right.

| 2 min read

What’s the Difference Between Gene Knockdown and Gene Knockout?

There are many techniques that allow scientists to silence a gene, but whether the effect is transient or permanent depends on the type of approach.

Cartoon of scientist deciding whether to go down the path of well-studied genes or that of the neglected genes.

| 5 min read

Stepping Into the Unknome

Image of the fly brain (grey) highlighting the population of neurons (pink) to which the gut-secreted peptide CCHa1 signals

| 3 min read

A Protein-Rich Diet Helps Mice and Flies Sleep More Soundly: Study

RNA interference

oxalate cystal rnai rna interference alnylam sirna lumasiran Oxlumo Patisiran Onpattro givosiran Givlaari galnac inclisiran

RNA Interference Comes of Age

Diana Kwon | | 6 min read

RNAi Mechanisms in Neurodegenerative Disease Therapy

Available on Demand

Image of the Day: Horns and Wings

Emily Makowski | | 2 min read

First RNAi Therapy Approved by FDA

Kerry Grens | | 1 min read

RNA Interference Drug Excels in Clinical Trials to Treat Rare Disorder

Katarina Zimmer | | 2 min read

CRISPR System Targets RNA in Mammalian Cells

Anna Azvolinsky | | 4 min read

Vitamin C Blocks Leukemia Progression in Mice

Aggie Mika | | 4 min read

RNAi’s Future in Drug-Target Screening

Catherine Offord | | 5 min read

A Walk on the Wild Side

Mary Beth Aberlin | | 3 min read

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An old medical illustration features the ear in the center with nerves of the head shown in yellow.

The Ear as a Therapeutic Gateway to the Vagus Nerve

Auricular vagal neuromodulation therapy is a non-invasive and non-surgical treatment that could aid cardiovascular disease management, Long COVID relief, and more.

Photo of John Calhoun crouches within his rodent utopia-turned-dystopia

Universe 25 Experiment

A series of rodent experiments showed that even with abundant food and water, personal space is essential to prevent societal collapse, but Universe 25's relevance to humans remains disputed.

3D illustration showing three differently colored semi-translucent cells, representing different T cell subtypes, on a black background. A purple cell is in the front on the right, a red cell is on the left, and a blue cell sits behind the red one.

T Cell Nomenclature Gets an Update

Improved technologies have allowed researchers to delve deeper into T cell biology, but the traditional naming scheme has struggled to keep up with new findings.

A yellow-colored frozen frog.

Freeze-Tolerant Frogs Power Organ Cryopreservation Strategies

Frogs that freeze themselves solid in the winter and thaw in the spring inspired methods to extend the storage time for transplantable organs.

Multimedia

Skip the Wait for Protein Stability Data with Aunty

Skip the Wait for Protein Stability Data with Aunty

In this webinar, Andre Mueller will discuss how scientists characterize therapeutic proteins in different formulations and spot the effects of excipients on protein stability.

Colorful abstract spiral dot pattern on a black background

Thermo Scientific X and S Series General Purpose Centrifuges

Thermo Scientific X and S Series General Purpose Centrifuges are designed to help provide exceptional performance, versatility and enhanced sustainability.

Illustration of a developing fetus surrounded by a clear fluid with a subtle yellow tinge, representing amniotic fluid.

January 2026, Issue 1

What Is the Amniotic Fluid Composed of?

The liquid world of fetal development provides a rich source of nutrition and protection tailored to meet the needs of the growing fetus.

View this Issue

Research Resources

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Skip the Wait for Protein Stability Data with Aunty

Skip the Wait for Protein Stability Data with Aunty

In this webinar, Andre Mueller will discuss how scientists characterize therapeutic proteins in different formulations and spot the effects of excipients on protein stability.

Graphic of three DNA helices in various colors

An Automated DNA-to-Data Framework for Production-Scale Sequencing

A streamlined, automated process helps scientists coordinate site-ready production-level whole genome sequencing results.

Exploring Cellular Organization with Spatial Proteomics

Exploring Cellular Organization with Spatial Proteomics

In this webinar, learn how scientists are using cutting-edge spatial proteomics technologies to advance their understanding of cellular organization in healthy and diseased tissues.

Abstract illustration of spheres with multiple layers, representing endoderm, ectoderm, and mesoderm derived organoids

Organoid Origins and How to Grow Them

Scientists rely on cytokines, growth factors, and other agents to direct and create different types of organoid models.

Products

Product News

BRANDTECH Scientific Introduces the Transferpette® pro Micropipette: A New Twist on Comfort and Control

The Transferpette® pro expands the Transferpette® family, offering scientists even greater flexibility to match their pipetting preferences and workflow requirements.

Biotium Launches GlycoLiner™ Cell Surface Glycoprotein Labeling Kits for Rapid and Selective Cell Surface Imaging

Fast, gentle, and highly specific glycoprotein labeling compatible with downstream immunofluorescence, enabled by next-generation aminooxy chemistry.

Colorful abstract spiral dot pattern on a black background

Thermo Scientific X and S Series General Purpose Centrifuges

Thermo Scientific X and S Series General Purpose Centrifuges are designed to help provide exceptional performance, versatility and enhanced sustainability.

Abstract background with red and blue laser lights

VANTAstar Flexible microplate reader with simplified workflows

VANTAstar Flexible microplate reader with simplified workflows