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Image of two speech bubbles. Inside the full white speech bubble, there is red text denoting The Scientist 40 Years, 1986-2026.
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RNA interference

Cartoon of scientist deciding whether to go down the path of well-studied genes or that of the neglected genes. 

Stepping Into the Unknome

Image of the fly brain (grey) highlighting the population of neurons (pink) to which the gut-secreted peptide CCHa1 signals

A Protein-Rich Diet Helps Mice and Flies Sleep More Soundly: Study

Calcium oxalate crystal in urine analysis, signifying the target of a new RNAi therapeutic.

RNA Interference Comes of Age

RNAi Mechanisms in Neurodegenerative Disease Therapy

Image of the Day: Horns and Wings

Abstract image of neuron cell network, signifying RNAi drug that targets the production of a mutated protein present in people with hereditary transthyretin amyloidosis

First RNAi Therapy Approved by FDA

RNA Interference Drug Excels in Clinical Trials to Treat Rare Disorder

CRISPR System Targets RNA in Mammalian Cells

Vitamin C Blocks Leukemia Progression in Mice

Trending

A team of cartoon scientists studying a giant pancreas.

Prolonged GLP-1 Exposure Remodels Gene Expression in the Pancreas by Flipping a Molecular Switch

A drawing of men and women holding boxes, resigning en mass from their jobs as editors.

Editors Mass Resign from Elsevier Journal After Editor-in-Chief Let Go

In the TS 40th Anniversary template, Sarkis Mazmanian smiles in a black and white headshot photo on the left. In a photo on the right, he stands in front of a large image of a cross-section of the brain. He wears a navy jacket, a white shirt, and glasses.

Then and Now: Sarkis Mazmanian Finds Gut-Brain Links to Parkinson’s Disease

Image of a Diploptera punctata cockroach.

Cockroach Milk Proteins Churn Out an Ig Nobel Win

Multimedia

Essential Genes Are Dominantly Activated by Single Transcription Factors

Essential Genes Are Dominantly Activated by Single Transcription Factors

EpiCypher Logo
Rethinking ALS Biomarkers: From Discovery to Clinical Impact

Rethinking ALS Biomarkers: From Discovery to Clinical Impact

Alamar Biosciences logo
The Scientist Digest cover September 2026
September 2026

Multiplex Microscopy Becomes Easier with Encoded Antibodies

A new system that enables researchers to uniquely tag monoclonal antibodies for use in microscopy could help simplify complex imaging studies.

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Essential Genes Are Dominantly Activated by Single Transcription Factors

Essential Genes Are Dominantly Activated by Single Transcription Factors

EpiCypher Logo
Rethinking ALS Biomarkers: From Discovery to Clinical Impact

Rethinking ALS Biomarkers: From Discovery to Clinical Impact

Alamar Biosciences logo
Engineering CAR-Neutrophils In Vivo to Target Glioblastoma

Engineering CAR-Neutrophils In Vivo to Target Glioblastoma

Miltenyi
Best Practices for qPCR Assay Design and Optimization

Best Practices for qPCR Assay Design and Optimization

Bio-Rad

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Single cells in suspension

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