Two cells on a purple background. Two mechanisms of gene silencing are shown in the cell on the left, while a double-strand break in a DNA region is shown in the cell on the right.

| 2 min read

What’s the Difference Between Gene Knockdown and Gene Knockout?

There are many techniques that allow scientists to silence a gene, but whether the effect is transient or permanent depends on the type of approach.

Cartoon of scientist deciding whether to go down the path of well-studied genes or that of the neglected genes.

| 5 min read

Stepping Into the Unknome

Image of the fly brain (grey) highlighting the population of neurons (pink) to which the gut-secreted peptide CCHa1 signals

| 3 min read

A Protein-Rich Diet Helps Mice and Flies Sleep More Soundly: Study

RNA interference

oxalate cystal rnai rna interference alnylam sirna lumasiran Oxlumo Patisiran Onpattro givosiran Givlaari galnac inclisiran

RNA Interference Comes of Age

Diana Kwon | | 6 min read

RNAi Mechanisms in Neurodegenerative Disease Therapy

Available on Demand

Image of the Day: Horns and Wings

Emily Makowski | | 2 min read

First RNAi Therapy Approved by FDA

Kerry Grens | | 1 min read

RNA Interference Drug Excels in Clinical Trials to Treat Rare Disorder

Katarina Zimmer | | 2 min read

CRISPR System Targets RNA in Mammalian Cells

Anna Azvolinsky | | 4 min read

Vitamin C Blocks Leukemia Progression in Mice

Aggie Mika | | 4 min read

RNAi’s Future in Drug-Target Screening

Catherine Offord | | 5 min read

A Walk on the Wild Side

Mary Beth Aberlin | | 3 min read

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Photo of John Calhoun crouches within his rodent utopia-turned-dystopia

Universe 25 Experiment

A series of rodent experiments showed that even with abundant food and water, personal space is essential to prevent societal collapse, but Universe 25's relevance to humans remains disputed.

Illustration of a hole in the shape of a dollar sign on a blue background. One character is falling into the hole at the bottom of the “S” while another individual is holding another up at the top of the “S”. The image represents the absence of funding for researchers in biotech with the cancellation of the SBIR/STTR program.

The Federal Government’s Research Innovation Lifeline Has Gone Dark

Congressional inaction has led to the expiration of the federal government’s SBIR/STTR program, cutting off a biotechnology lifeline.

The green zombie virus under the microscope, on a mottled yellow background.

What Are Giant Viruses, and Are They Dangerous?

Lurking in the vast expanse of the ocean and buried deep in the Siberian permafrost, there are giants—not blue whales and mammoths, but giant viruses.

Cartoon illustration of dead, rod-shaped bacteria, signifying Mycobacterium tuberculosis successfully defeated by antibiotics.

New “Kill Test” Could Help Screen Better Antibiotics

A new single cell-based screening tool evaluates how well antibiotics kill bacteria and may help researchers determine which drugs perform best in patients.

Multimedia

Redefining Immunology Through Advanced Technologies

Redefining Immunology Through Advanced Technologies

In this webinar, scientists will discuss innovations that are unlocking new insights into immunity.

Ensuring Regulatory Compliance in AAV Manufacturing with Analytical Ultracentrifugation

Ensuring Regulatory Compliance in AAV Manufacturing with Analytical Ultracentrifugation

In this webinar, Magdalena Pacewicz will highlight how to use AUC to characterize AAVs as part of ensuring regulatory compliance.

Illustration of a developing fetus surrounded by a clear fluid with a subtle yellow tinge, representing amniotic fluid.

January 2026

What Is the Amniotic Fluid Composed of?

The liquid world of fetal development provides a rich source of nutrition and protection tailored to meet the needs of the growing fetus.

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Redefining Immunology Through Advanced Technologies

Redefining Immunology Through Advanced Technologies

In this webinar, scientists will discuss innovations that are unlocking new insights into immunity.

Ensuring Regulatory Compliance in AAV Manufacturing with Analytical Ultracentrifugation

Ensuring Regulatory Compliance in AAV Manufacturing with Analytical Ultracentrifugation

In this webinar, Magdalena Pacewicz will highlight how to use AUC to characterize AAVs as part of ensuring regulatory compliance.

Skip the Wait for Protein Stability Data with Aunty

Skip the Wait for Protein Stability Data with Aunty

In this webinar, Andre Mueller will discuss how scientists characterize therapeutic proteins in different formulations and spot the effects of excipients on protein stability.

Graphic of three DNA helices in various colors

An Automated DNA-to-Data Framework for Production-Scale Sequencing

A streamlined, automated process helps scientists coordinate site-ready production-level whole genome sequencing results.

Products

Product News

Sino Biological's Launch of SwiftFluo® TR-FRET Kits Pioneers a New Era in High-Throughout Kinase Inhibitor Screening

Designed to balance ease of use, cost efficiency, and reproducible data, which are critical requirements for successful high-throughput screening campaigns

SPT Labtech enables automated Twist Bioscience NGS library preparation workflows on SPT's firefly platform

Automated Twist NGS library preparation workflows available on SPT Labtech’s firefly platform via the firefly cloud

Nuclera eProtein Discovery System installed at leading Universities in Taiwan

System strengthens Taiwan’s capabilities in protein drug discovery research

BRANDTECH Scientific Introduces the Transferpette® pro Micropipette: A New Twist on Comfort and Control

The Transferpette® pro expands the Transferpette® family, offering scientists even greater flexibility to match their pipetting preferences and workflow requirements.