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RNA Interference Drug Excels in Clinical Trials to Treat Rare Disorder
Katarina Zimmer | Nov 3, 2017
If approved, patisiran will be the first RNAi therapeutic on the market.
CRISPR System Targets RNA in Mammalian Cells
Anna Azvolinsky | Oct 4, 2017
Researchers engineer bacterial CRISPR-Cas13 to knock down RNA in mammalian cells.
Vitamin C Blocks Leukemia Progression in Mice
Aggie Mika | Aug 17, 2017
High-dose vitamin C injections reverse the effects of a leukemia-promoting genetic deficiency.
RNAi’s Future in Drug-Target Screening
Catherine Offord | Apr 17, 2017
A recent CRISPR study contradicted years of RNA interference research on a well-studied cancer drug target. But is it the last nail in the coffin for RNAi as a screening tool?
A Walk on the Wild Side
Mary Beth Aberlin | Feb 1, 2017
Plants have so much to teach us.
RNA Interference Between Kingdoms
Kerry Grens | Feb 1, 2017
Plants and fungi can use conserved RNA interference machinery to regulate each other’s gene expression—and scientists think they can make use of this phenomenon to create a new generation of pesticides.
Oligonucleotide Therapeutics Near Approval
Catherine Offord | Dec 1, 2016
Successful late-stage clinical trials could mark the maturation of a new drug development platform, but the path to commercialization is not without hurdles.
Gut Bacteria for Insect RNAi
Ruth Williams | Jun 1, 2016
Lacing insect food with microbes encoding double-stranded RNAs can suppress insect gene expression.
Metazoans in the DNAi Club
Amanda B. Keener | Jul 1, 2015
A chance discovery results in the first report of DNA-based gene silencing in an animal.
Ebola Drug Trial Terminated
Amanda B. Keener | Jun 23, 2015
Early analysis of TKM-Ebola-Guinea offers discouraging results, causing sponsors to end the Phase 2 trial.