Two cells on a purple background. Two mechanisms of gene silencing are shown in the cell on the left, while a double-strand break in a DNA region is shown in the cell on the right.
| 2 min read
There are many techniques that allow scientists to silence a gene, but whether the effect is transient or permanent depends on the type of approach.

RNA interference

oxalate cystal rnai rna interference alnylam sirna lumasiran Oxlumo Patisiran Onpattro givosiran Givlaari galnac inclisiran

RNA Interference Comes of Age

RNAi Mechanisms in Neurodegenerative Disease Therapy

Image of the Day: Horns and Wings

First RNAi Therapy Approved by FDA

RNA Interference Drug Excels in Clinical Trials to Treat Rare Disorder

CRISPR System Targets RNA in Mammalian Cells

Vitamin C Blocks Leukemia Progression in Mice

RNAi’s Future in Drug-Target Screening

A Walk on the Wild Side

RNA Interference Between Kingdoms

Oligonucleotide Therapeutics Near Approval

Gut Bacteria for Insect RNAi

Metazoans in the DNAi Club

Ebola Drug Trial Terminated

Improving Crops with RNAi

The Second Coming of RNAi

Karmella Haynes: Turning the Dials

Shushing RNA

Circular RNA Surprise

Going Boldly Forth

Trending

Photo of John Calhoun crouches within his rodent utopia-turned-dystopia

Universe 25 Experiment

Photo of a woman submerged in icy water with her head and clasped hands above water.

What are the Risks and Benefits of a Cold Plunge?

An illustration of mustard-colored mitochondria against a dark blue background.

Mitochondrial DNA: A Maternal Legacy That Helps Trace the Past and Diagnose the Future

A clipboard with the word “Sepsis” written at the top, surrounded by a syringe and medications.

A Common Antidepressant Protects Organs from Damage During Sepsis

Multimedia

Graphic of silver and gold 3D spheres levitating in space

Transform Omics Workflows with Scalable Cell Prep

LevitasBio
Conceptual image of genomic analysis showing multicolored DNA base sequences depicted as the letters C, G, A, and T.

Accelerating Cancer Research Through Comprehensive Genomic Analysis

Oxford Nanopore Technologies Logo
May digest 2025 cover
May 2025, Issue 1

Study Confirms Safety of Genetically Modified T Cells

A long-term study of nearly 800 patients demonstrated a strong safety profile for T cells engineered with viral vectors.

View this Issue
iStock

TaqMan Probe & Assays: Unveil What's Possible Together

Thermo Fisher Logo
Meet Aunty and Tackle Protein Stability Questions in Research and Development

Meet Aunty and Tackle Protein Stability Questions in Research and Development

Unchained Labs
Detecting Residual Cell Line-Derived DNA with Droplet Digital PCR

Detecting Residual Cell Line-Derived DNA with Droplet Digital PCR

Bio-Rad
How technology makes PCR instruments easier to use.

Making Real-Time PCR More Straightforward

Thermo Fisher Logo

Products

The Scientist Placeholder Image

Biotium Launches New Phalloidin Conjugates with Extended F-actin Staining Stability for Greater Imaging Flexibility

Leica Microsystems Logo

Latest AI software simplifies image analysis and speeds up insights for scientists

BioSkryb Genomics Logo

BioSkryb Genomics and Tecan introduce a single-cell multiomics workflow for sequencing-ready libraries in under ten hours

iStock

Agilent BioTek Cytation C10 Confocal Imaging Reader

agilent technologies logo