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RNA Interference Comes of Age
The third FDA approval of an RNAi-based therapeutic marks the growing success of a technique that took two decades to get off the ground.
RNA Interference Comes of Age
RNA Interference Comes of Age

The third FDA approval of an RNAi-based therapeutic marks the growing success of a technique that took two decades to get off the ground.

The third FDA approval of an RNAi-based therapeutic marks the growing success of a technique that took two decades to get off the ground.

RNA interference
Image of the Day: Horns and Wings
Emily Makowski | Nov 29, 2019 | 2 min read
Scarab beetle horns share a common genetic origin with wings.
First RNAi Therapy Approved by FDA
Kerry Grens | Aug 10, 2018 | 1 min read
Alnylam’s patisiran interferes with the production of a mutated protein present in people with hereditary transthyretin amyloidosis.
RNAi Mechanisms in Neurodegenerative Disease Therapy
The Scientist Creative Services Team | 1 min read
Experts will explore how RNAi mechanisms can modulate gene expression for the treatment of neurodegenerative diseases and how new methods for their use are being developed. 
RNA Interference Drug Excels in Clinical Trials to Treat Rare Disorder
Katarina Zimmer | Nov 3, 2017 | 2 min read
If approved, patisiran will be the first RNAi therapeutic on the market. 
CRISPR System Targets RNA in Mammalian Cells
Anna Azvolinsky | Oct 4, 2017 | 3 min read
Researchers engineer bacterial CRISPR-Cas13 to knock down RNA in mammalian cells.
Vitamin C Blocks Leukemia Progression in Mice
Aggie Mika | Aug 17, 2017 | 3 min read
High-dose vitamin C injections reverse the effects of a leukemia-promoting genetic deficiency.
RNAi’s Future in Drug-Target Screening
Catherine Offord | Apr 16, 2017 | 4 min read
A recent CRISPR study contradicted years of RNA interference research on a well-studied cancer drug target. But is it the last nail in the coffin for RNAi as a screening tool? 
A Walk on the Wild Side
Mary Beth Aberlin | Feb 1, 2017 | 3 min read
Plants have so much to teach us.
RNA Interference Between Kingdoms
Kerry Grens | Feb 1, 2017 | 10+ min read
Plants and fungi can use conserved RNA interference machinery to regulate each other’s gene expression—and scientists think they can make use of this phenomenon to create a new generation of pesticides.
Oligonucleotide Therapeutics Near Approval
Catherine Offord | Dec 1, 2016 | 8 min read
Successful late-stage clinical trials could mark the maturation of a new drug development platform, but the path to commercialization is not without hurdles.
Gut Bacteria for Insect RNAi
Ruth Williams | Jun 1, 2016 | 3 min read
Lacing insect food with microbes encoding double-stranded RNAs can suppress insect gene expression.
Metazoans in the DNAi Club
Amanda B. Keener | Jul 1, 2015 | 2 min read
A chance discovery results in the first report of DNA-based gene silencing in an animal.
Ebola Drug Trial Terminated
Amanda B. Keener | Jun 23, 2015 | 2 min read
Early analysis of TKM-Ebola-Guinea offers discouraging results, causing sponsors to end the Phase 2 trial.
Improving Crops with RNAi
Narender Nehra and Nigel Taylor | Jun 1, 2015 | 2 min read
RNA interference is proving to be a valuable tool for agriculture, allowing researchers to develop pathogen-resistant and more-nutritious crops.
The Second Coming of RNAi
Eric Bender | Sep 1, 2014 | 10+ min read
Now showing clinical progress against liver diseases, the gene-silencing technique begins to fulfill some of its promises.
Karmella Haynes: Turning the Dials
Kerry Grens | Dec 1, 2013 | 3 min read
Assistant Professor, Arizona State University. Age: 36
Shushing RNA
Edyta Zielinska | Aug 1, 2013 | 2 min read
The cell detains potentially harmful RNA messages in the spliceosome long enough to create interfering RNAs against the aberrant messages.
Circular RNA Surprise
Dan Cossins | Feb 28, 2013 | 2 min read
Previously enigmatic circular RNAs have been found to influence gene expression by binding to and blocking another class of regulatory RNA, the microRNAs.
Going Boldly Forth
Karen Hopkin | Jan 1, 2013 | 9 min read
Gregory Hannon believes in taking risks—an approach that’s enabled him to make exciting new discoveries in the world of small RNAs.
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