Man in personal protective equipment (glasses, gloves, cap, and coat) watching plants go through a piece of machinery.
Canada Approves World’s First Plant-Based COVID-19 Vaccine
Canada has ordered 76 million doses of Covifenz, the main ingredient of which was manufactured in the leaves of a tobacco relative.
ABOVE: Medicago
Canada Approves World’s First Plant-Based COVID-19 Vaccine
Canada Approves World’s First Plant-Based COVID-19 Vaccine

Canada has ordered 76 million doses of Covifenz, the main ingredient of which was manufactured in the leaves of a tobacco relative.

Canada has ordered 76 million doses of Covifenz, the main ingredient of which was manufactured in the leaves of a tobacco relative.

ABOVE: Medicago

vaccine trials

line of people waiting outside mass vaccination site
“Nocebo” Effect May Cause Majority of COVID-19 Vaccine Symptoms
Natalia Mesa | Jan 18, 2022
A negative version of the placebo effect may be behind many instances of mild side effects associated with the jabs, a study suggests.
building sign
Johnson & Johnson Vaccine Garners First Full Approval
Chloe Tenn | Nov 24, 2021
Health Canada has given the single COVID-19 shot the official greenlight for use in people 18 and older.
black-legged deer tick waits on leaf for host to feed on
A Lab-Stage mRNA Vaccine Targeting Ticks May Offer Protection Against Lyme and Other Tick-Borne Diseases
Andaleeb Sajid | Nov 18, 2021
NIH researcher Andaleeb Sajid discusses her study’s finding that ticks were unable to feed on vaccinated guinea pigs, preventing transmission of the pathogen that causes Lyme disease.
close-up of a mosquito on human skin
Hope, Concern Surround WHO Green Light of First Malaria Vaccine
Katarina Zimmer | Oct 28, 2021
RTS,S has several flaws but could still save tens of thousands of lives, experts say.
a pill bottle with dice spilling out
Book Excerpt from You Bet Your Life
Paul A. Offit | Sep 21, 2021
In his book’s Introduction, physician-scientist Paul A. Offit reviews the unusual constellation of circumstances around the development of COVID-19 vaccines.
Updated Mar 8
A healthcare worker holds up three syringes with clear medicine
To Booster or Not: Scientists and Regulators Debate
Jef Akst | Sep 16, 2021
President Biden’s planned rollout of additional COVID-19 vaccine doses is set to begin next week, but questions remain about who should get them.
Illustration of the BCG vaccine and resulting immune response
Infographic: TB Vaccines in the Pipeline Take Varied Approaches
Anthony King | Jul 1, 2021
More than a dozen vaccines for tuberculosis are currently being tested in clinical trials. Some use whole bacteria as BCG does, while others deliver protein subunits or genetic material carried by viral vectors.  
False-colored micrograph of Mycobacterium tuberculosis
Tuberculosis: The Forgotten Pandemic
Anthony King | Jul 1, 2021
This month marks the 100-year anniversary of BCG, still the only approved vaccine against the lethal pathogen. But there are new vaccines for this wily foe on the horizon.
Pharma, US Government Plan for COVID-19 Booster Shots
Jef Akst | Apr 16, 2021
It’s unclear how long protections against infection will last from the initial vaccinations, and health authorities say additional jabs will likely be necessary.
Bile and Potatoes, 1921
Jef Akst | Apr 1, 2021
One hundred years after its invention, BCG has stood the test of time as a vaccine against tuberculosis.
COVID-19, SARS-CoV-2, coronavirus, pandemic, vaccine, vaccine trials, combination, mix and match, immunity, antibodies, T cells, Pfizer, Moderna, AstraZeneca, clinical trials
COVID-19 Vaccine Combos Aim to Boost Immunity
Asher Jones | Mar 9, 2021
Mix-and-match shots could simplify vaccine rollout and stimulate more-robust immune responses. Ongoing clinical trials will soon give answers.
SARS-CoV-2, COVID-19, coronavirus, pandemic, virus, vaccine, vaccination, outbreak, infectious disease, Johnson & Johnson, Moderna, Pfizer, drug development
One-Shot COVID-19 Vaccine Prevents Severe Disease
Asher Jones | Jan 29, 2021
Johnson & Johnson’s vaccine is less effective at preventing COVID-19 than other approved vaccines are, but experts say it could still be an important tool in curbing the pandemic.
2020 in Scientists’ Own Words
Abby Olena | Dec 23, 2020
The world was rocked by the COVID-19 pandemic this year, but researchers rose to all manner of challenges.
Infographic: How Vaccines Train Innate Immunity
Shawna Williams | Nov 1, 2020
A recent study elucidates some of the changes that occur in the body after inoculation with a tuberculosis vaccine.
How Some Vaccines Protect Against More than Their Targets
Shawna Williams | Nov 1, 2020
As researchers test existing vaccines for nonspecific protection against COVID-19, immunologists are working to understand how some inoculations protect against pathogens they weren’t designed to fend off.
Trials Unlikely to Show if COVID-19 Vaccine Prevents Severe Cases
Max Kozlov | Oct 30, 2020
A vaccine expert explains that such answers likely won’t come until a vaccine has already been approved and administered to millions of people.
A Challenge Trial for COVID-19 Would Not Be the First of Its Kind
Jef Akst | Oct 8, 2020
Although scientists debate the ethics of deliberately infecting volunteers with SARS-CoV-2, plenty of consenting participants have been exposed to all sorts of pathogens in prior trials.
COVID-19, SARS-CoV-2, coronavirus, pandemic, AstraZeneca, University of Oxford, clinical trial, adverse effects, safety, FDA
COVID-19 Vaccine Trial Pauses After Adverse Reaction
Amanda Heidt | Sep 9, 2020
The hold will likely delay trial results, and scientists say the pause is proof that safety protocols in clinical trials are working as they should.
Russia Approves World’s First Coronavirus Vaccine
Jef Akst | Aug 11, 2020
Some researchers express skepticism given the lack of data about the vaccine’s safety and efficacy, and the country plans to vaccinate healthcare workers, teachers, and others even before testing is complete.