To Booster or Not: Scientists and Regulators Debate
To Booster or Not: Scientists and Regulators Debate
President Biden’s planned rollout of additional COVID-19 vaccine doses is set to begin next week, but questions remain about who should get them.
To Booster or Not: Scientists and Regulators Debate
To Booster or Not: Scientists and Regulators Debate

President Biden’s planned rollout of additional COVID-19 vaccine doses is set to begin next week, but questions remain about who should get them.

President Biden’s planned rollout of additional COVID-19 vaccine doses is set to begin next week, but questions remain about who should get them.

vaccine trials
Infographic: TB Vaccines in the Pipeline Take Varied Approaches
Infographic: TB Vaccines in the Pipeline Take Varied Approaches
Anthony King | Jul 1, 2021
More than a dozen vaccines for tuberculosis are currently being tested in clinical trials. Some use whole bacteria as BCG does, while others deliver protein subunits or genetic material carried by viral vectors.  
Tuberculosis: The Forgotten Pandemic
Tuberculosis: The Forgotten Pandemic
Anthony King | Jul 1, 2021
This month marks the 100-year anniversary of BCG, still the only approved vaccine against the lethal pathogen. But there are new vaccines for this wily foe on the horizon.
Pharma, US Government Plan for COVID-19 Booster Shots
Pharma, US Government Plan for COVID-19 Booster Shots
Jef Akst | Apr 16, 2021
It’s unclear how long protections against infection will last from the initial vaccinations, and health authorities say additional jabs will likely be necessary.
Bile and Potatoes, 1921
Bile and Potatoes, 1921
Jef Akst | Apr 1, 2021
One hundred years after its invention, BCG has stood the test of time as a vaccine against tuberculosis.
COVID-19 Vaccine Combos Aim to Boost Immunity
COVID-19 Vaccine Combos Aim to Boost Immunity
Asher Jones | Mar 9, 2021
Mix-and-match shots could simplify vaccine rollout and stimulate more-robust immune responses. Ongoing clinical trials will soon give answers.
One-Shot COVID-19 Vaccine Prevents Severe Disease
One-Shot COVID-19 Vaccine Prevents Severe Disease
Asher Jones | Jan 29, 2021
Johnson & Johnson’s vaccine is less effective at preventing COVID-19 than other approved vaccines are, but experts say it could still be an important tool in curbing the pandemic.
2020 in Scientists’ Own Words
2020 in Scientists’ Own Words
Abby Olena | Dec 23, 2020
The world was rocked by the COVID-19 pandemic this year, but researchers rose to all manner of challenges.
Infographic: How Vaccines Train Innate Immunity
Infographic: How Vaccines Train Innate Immunity
Shawna Williams | Nov 1, 2020
A recent study elucidates some of the changes that occur in the body after inoculation with a tuberculosis vaccine.
How Some Vaccines Protect Against More than Their Targets
How Some Vaccines Protect Against More than Their Targets
Shawna Williams | Nov 1, 2020
As researchers test existing vaccines for nonspecific protection against COVID-19, immunologists are working to understand how some inoculations protect against pathogens they weren’t designed to fend off.
Trials Unlikely to Show if COVID-19 Vaccine Prevents Severe Cases
Trials Unlikely to Show if COVID-19 Vaccine Prevents Severe Cases
Max Kozlov | Oct 30, 2020
A vaccine expert explains that such answers likely won’t come until a vaccine has already been approved and administered to millions of people.
A Challenge Trial for COVID-19 Would Not Be the First of Its Kind
A Challenge Trial for COVID-19 Would Not Be the First of Its Kind
Jef Akst | Oct 8, 2020
Although scientists debate the ethics of deliberately infecting volunteers with SARS-CoV-2, plenty of consenting participants have been exposed to all sorts of pathogens in prior trials.
COVID-19 Vaccine Trial Pauses After Adverse Reaction
COVID-19 Vaccine Trial Pauses After Adverse Reaction
Amanda Heidt | Sep 9, 2020
The hold will likely delay trial results, and scientists say the pause is proof that safety protocols in clinical trials are working as they should.
Russia Approves World’s First Coronavirus Vaccine
Russia Approves World’s First Coronavirus Vaccine
Jef Akst | Aug 11, 2020
Some researchers express skepticism given the lack of data about the vaccine’s safety and efficacy, and the country plans to vaccinate healthcare workers, teachers, and others even before testing is complete.
FDA to Require 50 Percent Efficacy for COVID-19 Vaccines
FDA to Require 50 Percent Efficacy for COVID-19 Vaccines
Amanda Heidt | Jul 1, 2020
Vaccine experts divided on whether that level of protection is too low or too demanding.
Humans Inoculated with Genetically Modified Malaria Parasites
Humans Inoculated with Genetically Modified Malaria Parasites
Ruth Williams | May 20, 2020
Engineered Plasmodium parasites form the basis of two experimental malaria vaccines that showed safety and encouraging immune responses in clinical trials.
Support for Vaccine Challenge Trials Gains Momentum
Support for Vaccine Challenge Trials Gains Momentum
Shawna Williams | May 11, 2020
The idea of deliberately infecting volunteers with SARS-CoV-2 has garnered significant attention as a potential avenue to speedier development, as the World Health Organization weighs in with recommendations.
Updated Aug 9
BARDA Director Departs Post Overseeing COVID-19 Vaccine Efforts
BARDA Director Departs Post Overseeing COVID-19 Vaccine Efforts
Jef Akst | Apr 22, 2020
Rick Bright will no longer head the Biomedical Advanced Research and Development Authority and will instead work at the National Institutes of Health on diagnostics for SARS-CoV-2 infection.
Updated July 9
Track COVID-19 Vaccines Advancing Through Clinical Trials
Track COVID-19 Vaccines Advancing Through Clinical Trials
The Scientist Staff | Apr 7, 2020
Find the latest updates in this one-stop resource, including efficacy data and side effects of approved shots, as well as progress on new candidates entering human studies.
Bioethicists Criticize WHO’s Malaria Vaccine Trial
Bioethicists Criticize WHO’s Malaria Vaccine Trial
Lisa Winter | Feb 28, 2020
The study, conducted in Malawi, Kenya, and Ghana, did not obtain informed consent from each parent whose child participated, but rather considered consent “implied” because of the particular experimental design.