A Challenge Trial for COVID-19 Would Not Be the First of Its Kind
A Challenge Trial for COVID-19 Would Not Be the First of Its Kind
Although scientists debate the ethics of deliberately infecting volunteers with SARS-CoV-2, plenty of consenting participants have been exposed to all sorts of pathogens in prior trials.
A Challenge Trial for COVID-19 Would Not Be the First of Its Kind
A Challenge Trial for COVID-19 Would Not Be the First of Its Kind

Although scientists debate the ethics of deliberately infecting volunteers with SARS-CoV-2, plenty of consenting participants have been exposed to all sorts of pathogens in prior trials.

Although scientists debate the ethics of deliberately infecting volunteers with SARS-CoV-2, plenty of consenting participants have been exposed to all sorts of pathogens in prior trials.

vaccine trials
COVID-19 Vaccine Trial Pauses After Adverse Reaction
COVID-19 Vaccine Trial Pauses After Adverse Reaction
Amanda Heidt | Sep 9, 2020
The hold will likely delay trial results, and scientists say the pause is proof that safety protocols in clinical trials are working as they should.
Russia Approves World’s First Coronavirus Vaccine
Russia Approves World’s First Coronavirus Vaccine
Jef Akst | Aug 11, 2020
Some researchers express skepticism given the lack of data about the vaccine’s safety and efficacy, and the country plans to vaccinate healthcare workers, teachers, and others even before testing is complete.
FDA to Require 50 Percent Efficacy for COVID-19 Vaccines
FDA to Require 50 Percent Efficacy for COVID-19 Vaccines
Amanda Heidt | Jul 1, 2020
Vaccine experts divided on whether that level of protection is too low or too demanding.
Humans Inoculated with Genetically Modified Malaria Parasites
Humans Inoculated with Genetically Modified Malaria Parasites
Ruth Williams | May 20, 2020
Engineered Plasmodium parasites form the basis of two experimental malaria vaccines that showed safety and encouraging immune responses in clinical trials.
Support for Vaccine Challenge Trials Gains Momentum
Support for Vaccine Challenge Trials Gains Momentum
Shawna Williams | May 11, 2020
The idea of deliberately infecting volunteers with SARS-CoV-2 has garnered significant attention as a potential avenue to speedier development, as the World Health Organization weighs in with recommendations.
BARDA Director Departs Post Overseeing COVID-19 Vaccine Efforts
BARDA Director Departs Post Overseeing COVID-19 Vaccine Efforts
Jef Akst | Apr 22, 2020
Rick Bright will no longer head the Biomedical Advanced Research and Development Authority and will instead work at the National Institutes of Health on diagnostics for SARS-CoV-2 infection.
Updated Oct 26
COVID-19 Vaccine Frontrunners
COVID-19 Vaccine Frontrunners
Jef Akst | Apr 7, 2020
Stay up-to-date on the progress of dozens of vaccine candidates that are currently undergoing clinical testing.
Bioethicists Criticize WHO’s Malaria Vaccine Trial
Bioethicists Criticize WHO’s Malaria Vaccine Trial
Lisa Winter | Feb 28, 2020
The study, conducted in Malawi, Kenya, and Ghana, did not obtain informed consent from each parent whose child participated, but rather considered consent “implied” because of the particular experimental design.
Dengue Vaccine Trial Results Show Promise, with Caveats
Dengue Vaccine Trial Results Show Promise, with Caveats
Shawna Williams | Nov 8, 2019
TAK-003 appears to avoid the safety issues seen with an existing vaccine, but experts say a longer evaluation is needed.