The One True Path?

By Jennifer Welsh The One True Path? Several groups of scientists are finding clues that suggest many major illnesses result from disruptions to one complex molecular cascade—insulin signaling. ndocrinologist Kevin Niswender and neuroscientist Aurelio Galli hadn’t really kept in contact since they parted ways after beginning their respective careers at Vanderbilt University in the 1990s. But about 10 years ago, Niswender, who went to medical school

Written byJennifer Welsh
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ndocrinologist Kevin Niswender and neuroscientist Aurelio Galli hadn’t really kept in contact since they parted ways after beginning their respective careers at Vanderbilt University in the 1990s. But about 10 years ago, Niswender, who went to medical school at Vanderbilt, and Galli, who did a postdoc there, both landed faculty positions back at the Nashville, Tennessee, university. They rekindled their friendship and often discussed their research during convivial family dinners.

Gene Networks Underlie Disease?

Insulin Regulates Translation

Die, Diabetes

Niswender, who studies diabetes and metabolism, and Galli, who specializes in the neurobiology of addiction, had never collaborated scientifically. They can’t remember the exact moment they decided to do so, but gradually they realized that some of their research interests overlapped. The pair discussed a number of clinical hints that diabetes and mood disorders are related: Defects of the insulin pathway run in families with schizophrenia, diabetics are more likely to ...

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