Slime mold fruiting body.IMAGE: DANIEL J. DICKINSON, PROGRAM IN CANCER BIOLOGY, STANFORD UNIVERSITY
Cancer cells invade en mass when actomyosin is downregulated at cell-cell contacts. Blocking that downregulation by depleting a cell matrix adhesion protein called DDR1 leads to increased actomyosin activity and poor cancer cell migration.
C. Hidalgo-Carcedo, et al., "Collective cell migration requires suppression of actomyosin at cell-cell contacts mediated by DDR1 and the cell polarity regulators Par3 and Par6," Nat Cell Bio, 13:49-58, 2011. Evaluations by Adi Dubash and Kathleen J Green, Northwestern Univ Med School; Roberto Mayor, Univ College London; Martin A Schwartz, Univ of Virginia; Michael Dohn and Albert Reynolds, Vanderbilt University; Richard Klemke, Univ of California, San Diego. Free F1000 Evaluation
A simple slime mold may not be as dissimilar from complex multicellular creatures as ...
