linkurl:1. A shared anesthetic binding site; Though general anesthetics are commonly used in medicine, how they work on a molecular level is poorly understood. New research suggests that certain ligand-gated ion channels share a binding site for a couple different general anesthetics; knowledge which could help in the development of new drugs.H. Nury et al., linkurl:"X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel," Nature, 469:428-31, 2011.; Evaluations by Ashley Fiamengo and Roderic Eckenhoff, UPenn; Edward Bertaccini, Stanford Univ Sch Med; Douglas Raines, Mass Gen Hosp; Gregg Homanics Univ Pitt; Stuart Forman, Mass Gen Hosp; Xiangdong Chen and Douglas Bayliss Univ Virg Hlth Sci Cntr. linkurl:Free F1000 Evaluation; linkurl:2. A new C. diff treatment?;
Clostridium difficile colonies
Image: Wikimedia commons, CDC/Dr. Holdeman
The antibiotic vancomycin is the standard treatment for infection by increasingly virulent strains of Clostridium difficile, but recurrence rates are high. A...
T.J. Louie et al., linkurl:" Fidaxomicin versus vancomycin for Clostridium difficile infection," N Engl J Med, 364:422-31, 2011.; Evaluations by Carmel Curtis and Peter Wilson, Univ Coll Lon Hosp; Joyce Popoola, St George's Hosp, UK; Venkataraman Subramanian, Univ Nottingham; Vinay Acharya and Tor Savidge, Univ TX Med Branch. linkurl:Free F1000 Evaluation; linkurl:3. Better ventilation, more transplantable lungs; L. Mascia et al., linkurl:"Effect of a lung protective strategy for organ donors on eligibility and availability of lungs for transplantation: a randomized controlled trial," JAMA, 304:2620-7, 2010.; Evaluations by Alexander Benson and Ivor Douglas, Univ CO Denver Hlth; Thomas Luecke, Univ Hosp Mannheim, Univ Heidelberg; Claude Guerin, Hospices Civils de Lyon. linkurl:Free F1000 Evaluation; linkurl:4. A mechanism for endocrine tumor troubles; M. Choi et al., linkurl:"K+ channel mutations in adrenal aldosterone-producing adenomas and hereditary hypertension," Science, 331:768-72, 2010.; Evaluations by Peter J Fuller, Prince Henry's Inst of Med Rsrch, Australia; Lee S Weinstein, NIDDK/NIH. linkurl:Free F1000 Evaluation; linkurl:5. The microRNA behind hypertension; A. Courboulin et al., linkurl:"Role for miR-204 in human pulmonary arterial hypertension," J Exp Med, 208:535-48, 2011.; Evaluations by Brian Graham, James Hunt and Rubin Tuder, Univ CO Denver; Matthias Brock and Lars Huber, Univ Hospl Zurich. linkurl:Free F1000 Evaluation; linkurl:6. New molecular phenotypes for asthma; P.G. Woodruff et al., linkurl:"T-helper type 2-driven inflammation defines major subphenotypes of asthma," Am J Respir Crit Care Med, 180:388-95, 2009.; Evaluations by Bradley Chipps, Capital Allergy and Respiratory Cntr; Pranab Haldar, Inst Lung Health, UK; Kristie Ross and James Chmiel, Case Western Reserve Univ; Bruce Levy, Brigham & Women's Hosp. linkurl:Free F1000 Evaluation; linkurl:7. Real time tracking of kidney damage; N. Paragas et al., linkurl:"The Ngal reporter mouse detects the response of the kidney to injury in real time," Nat Med, 17:216-22, 2011.; Evaluations by Florian Toegel and Christof Westenfelder, Univ Utah Med Cntrs; Matthieu Legrand, Lariboisière Hosp. linkurl:Free F1000 Evaluation;

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