Transforming 3D biology using AI: Tomocube’s HT-X1™ Plus accelerates cellular and organoids label-free analysis

This new system raises the bar in high-resolution, high-throughput 3D imaging for cells and organoids, providing researchers with faster, more detailed, and more accurate insights into biological processes.

| 2 min read

Register for free to listen to this article
Listen with Speechify
0:00
2:00
Share

Tomocube, a global leader in 3D label-free imaging and analysis, proudly introduces the HT-X1™ Plus, a state-of-the-art bioimaging platform designed to meet the evolving needs of biomedical researchers. This new system raises the bar in high-resolution, high-throughput 3D imaging for cells and organoids, providing researchers with faster, more detailed, and more accurate insights into biological processes.

With the HT-X1™ Plus, Tomocube has integrated cutting-edge technologies that enhance precision, imaging speed, and data richness. The platform offers a 4x larger field of view and advanced illumination optics, making it a game-changer for phenotypic screening, tissue section imaging, and the study of fast-moving microorganisms. These capabilities unlock new research possibilities in cell biology, regenerative medicine, and organoids research.

Setting New Standards in 3D Imaging

Building upon the proven success of the HT-X1™, the HT-X1™ Plus sets new standards in 3D imaging performance. Equipped with a high-performance CXP camera and AI-powered image reconstruction algorithms, the platform drastically reduces scan times, enabling comprehensive 3D imaging of a full 96-well plate in under 30 minutes—without sacrificing detail or quality. “With the HT-X1™ Plus, researchers can now explore complex biological samples like organoids with unparalleled clarity and speed,” said YongKeun (Paul) Park, Chief Executive Officer in Tomocube. “This platform is designed for high-content, image-based drug screening assays and holds tremendous potential to accelerate discoveries in biomedical research.”

Key Features of the HT-X1™ Plus Include:

  • Larger Field-of-View: Capture expansive areas without stitching, ideal for large-scale, high-content experiments.
  • Faster Image Acquisition: Optimized for high-throughput screening, capable of scanning 96-well plates in just 30 minutes.
  • Flexible Light Source Options: Configure imaging with three wavelengths (R/G/B) for optimal contrast and penetration.
  • Advanced Correlative Fluorescence Imaging: Integrated sCMOS-based fluorescence module (FLX™) enhances 3D imaging with high sensitivity and precision.
  • Color Brightfield Imaging: A new modality with wide preview scan mode improves histological studies, providing comprehensive tissue morphology analysis.
Tomocube HT-X1™ Plus

Solving Major Research Challenges:

The HT-X1™ Plus directly addresses key challenges in bioimaging, including slow scan speeds, limited fluorescence sensitivity, and challenges related to light absorption in thick samples. Its advanced imaging capabilities—such as reduced phototoxicity and improved 3D optical sectioning—make it the ideal tool for investigating dynamic, sensitive samples without compromising image quality.

Pushing the Boundaries of Biomedical Discovery:

Designed to integrate effortlessly with molecular studies and fluorescence-tagged sensors, the HT-X1™ Plus enables researchers to visualize and quantify intricate biological processes with unprecedented detail. The platform’s AI-driven TomoAnalysis™ software facilitates in-depth analysis, further pushing the boundaries of cellular dynamics research.

Applications of HT-X1™ Plus Include:

  • Cell Biology & Regenerative Medicine: Perform high-content screening of live cells and organoids for drug discovery and therapeutic studies.
  • 3D Biology & Organoids: Obtain detailed imaging of dense organoids, tissue sections, and immune cell interactions.


Is the form not loading? If you use an ad blocker or browser privacy features, try turning them off and refresh the page.

You might also be interested in...
Loading Next Article...
You might also be interested in...
Loading Next Article...
Image of small blue creatures called Nergals. Some have hearts above their heads, which signify friendship. There is one Nergal who is sneezing and losing health, which is denoted by minus one signs floating around it.
June 2025, Issue 1

Nergal Networks: Where Friendship Meets Infection

A citizen science game explores how social choices and networks can influence how an illness moves through a population.

View this Issue
An illustration of green lentiviral particles.

Maximizing Lentivirus Recovery

cytiva logo
Unraveling Complex Biology with Advanced Multiomics Technology

Unraveling Complex Biology with Five-Dimensional Multiomics

Element Bioscience Logo
Resurrecting Plant Defense Mechanisms to Avoid Crop Pathogens

Resurrecting Plant Defense Mechanisms to Avoid Crop Pathogens

Twist Bio 
The Scientist Placeholder Image

Seeing and Sorting with Confidence

BD

Products

The Scientist Placeholder Image

Agilent Unveils the Next Generation in LC-Mass Detection: The InfinityLab Pro iQ Series

The Scientist Placeholder Image

Agilent Announces the Enhanced 8850 Gas Chromatograph

parse-biosciences-logo

Pioneering Cancer Plasticity Atlas will help Predict Response to Cancer Therapies