Illustration of a human and Neanderthal skull side by side.
Mutation Linked to Difference Between Human and Neanderthal Brains
A single amino acid substitution in a protein causes increased neuron production in the frontal lobes of humans compared to Neanderthals—a tiny difference that could have given our species a cognitive edge, researchers say.
Mutation Linked to Difference Between Human and Neanderthal Brains
Mutation Linked to Difference Between Human and Neanderthal Brains

A single amino acid substitution in a protein causes increased neuron production in the frontal lobes of humans compared to Neanderthals—a tiny difference that could have given our species a cognitive edge, researchers say.

A single amino acid substitution in a protein causes increased neuron production in the frontal lobes of humans compared to Neanderthals—a tiny difference that could have given our species a cognitive edge, researchers say.

organoids
Fluorescent microscopy of a healthy intestinal organoid and a tumor spheroid
Internal Clock Disruptions Increase Colon Cancer Risk in Mice
Shafaq Zia | Aug 19, 2022
Disturbing circadian rhythms in organoids and mice increases intestinal tumor growth, findings that may explain a recent rise in colon cancer among young adults, the researchers behind the work say.
Microscopy image showing patches of magenta and green
Three Autism-Linked Genes Converge on Tweaks to Cells’ Timing
Angie Voyles Askham, Spectrum | Feb 3, 2022
The genes are involved in pacing the development of inhibitory and excitatory neurons. An imbalance in these two types of signaling is thought to play a role in autism.
Capturing Brain Complexity in Assembloids
Capturing Brain Complexity in Assembloids
The Scientist Creative Services Team
In this webinar, Jimena Anderson and Jens Schwamborn will describe the next-generation brain organoids that combine multiple brain regions and cell types in 3D cultures.
photo of a researcher looking in a microscope fertilising an egg via intracytoplasmic sperm injection.
Human Stem Cell Research Guidelines Updated
Ruth Williams | May 26, 2021
Removal of the 14-day limit for culturing human embryos is one of the main changes in the revised recommendations from the International Society for Stem Cell Research.
ethics, bioethics, brain organoid, chimera, cell transplant, Q&A, report, NIH, NAS, neuroscience, Techniques, disease & medicine, immunology, psychiatric conditions
New Report Dissects Ethics of Emerging Human Brain Cell Models
Amanda Heidt | Apr 12, 2021
The National Academies’ report touches on ethical issues raised by new technologies such as brain organoids and human-animal chimeras, and suggests that current regulatory oversight is sufficient.
A Brief History of Stem Cells
Scientific Breakthroughs with Stem Cells
Nele Haelterman, PhD
Discover the various ways scientists bolster stem cells to understand and cure disease.
Organoids Repair Bile Ducts
Abby Olena | Feb 18, 2021
Researchers determined that when introduced into damaged mouse or donated human livers, these lab-grown tissues could integrate into bile ducts and function normally.
Gene-Edited Organoids Explore Neanderthal Brain Function
Jef Akst | Feb 12, 2021
Using CRISPR to swap an archaic variant of the NOVA1 gene into human stem cells, researchers create organoids with neurodevelopmental differences from those carrying modern DNA.
Mini organs in a dish
Brush Up: What Are Organoids and How Are They Made?
Jennifer Zieba, PhD
Miniaturized, in vitro versions of organs provide insights into disease and development.
The Many Model Systems of COVID-19
Abby Olena | Nov 4, 2020
Researchers turn to familiar model animals, along with some fresh strategies, to develop countermeasures against SARS-CoV-2 and investigate the biology of infection.
organoid human brain sars-cov-2 covid-19 coronavirus pandemic ac2 receptor neurological symptoms central nervous system
SARS-CoV-2 Can Infect Human Brain Organoids
Katarina Zimmer | Jul 9, 2020
The results are a proof-of-concept that the novel coronavirus can replicate in neurons, but it’s too soon to say whether this occurs in people with COVID-19.
in love with the shape of you
In Love with the Shape of You: Physical Scaffolding Defines Organoid Patterning
Sejal Davla, PhD
Controlling a growing tissue’s shape achieves deterministic and uniform patterning in intestinal organoids.
Zika as Cancer Buster?
Amy Schleunes | Apr 1, 2020
By infecting glioblastoma cells but not healthy brain tissue, some form of the virus could serve a therapeutic purpose.
snake venom stem cells
Snake Venom Gland Organoids Produce Functional Toxins
Amy Schleunes | Jan 24, 2020
Stem cells from nine snake species respond to tissue culturing techniques previously used only on mouse and human stem cells.
 somite organoid in culture
Reconstructing How the Spine Takes its Shape
Nele Haelterman, PhD
Marina Sanaki-Matsumiya figured out how to grow human somites in a dish through a process that mirrors the tissue’s development in the embryo.
Sergiu Pasca Builds Brains to Study Developmental Disease
Emily Makowski | Dec 1, 2019
The Stanford University professor helped develop a technique to grow brain organoids from induced pluripotent stem cells.
Organoids Don’t Accurately Model Human Brain Development
Diana Kwon | Oct 23, 2019
A new study suggests that growing in a stressful environment prevents “brains-in-a-dish” from growing in the same way as their in vivo counterparts.
Next-Level Organoids
Next-Level Organoids
The Scientist Creative Services Team
Researchers use organoid cultures in unique ways to study health and disease.
Image of the Day: Patient-Derived Organoids
Emily Makowski | Oct 10, 2019
Three-dimensional tissue cultures grown from cancer patients’ own tumors can predict responses to the drug irinotecan.