Microscopy image showing patches of magenta and green
Three Autism-Linked Genes Converge on Tweaks to Cells’ Timing
The genes are involved in pacing the development of inhibitory and excitatory neurons. An imbalance in these two types of signaling is thought to play a role in autism.
ABOVE: Paola Arlotta laboratory at Harvard University and Kwanghun Chung laboratory at MIT
Three Autism-Linked Genes Converge on Tweaks to Cells’ Timing
Three Autism-Linked Genes Converge on Tweaks to Cells’ Timing

The genes are involved in pacing the development of inhibitory and excitatory neurons. An imbalance in these two types of signaling is thought to play a role in autism.

The genes are involved in pacing the development of inhibitory and excitatory neurons. An imbalance in these two types of signaling is thought to play a role in autism.

ABOVE: Paola Arlotta laboratory at Harvard University and Kwanghun Chung laboratory at MIT

organoids

photo of a researcher looking in a microscope fertilising an egg via intracytoplasmic sperm injection.
Human Stem Cell Research Guidelines Updated
Ruth Williams | May 26, 2021
Removal of the 14-day limit for culturing human embryos is one of the main changes in the revised recommendations from the International Society for Stem Cell Research.
ethics, bioethics, brain organoid, chimera, cell transplant, Q&A, report, NIH, NAS, neuroscience, Techniques, disease & medicine, immunology, psychiatric conditions
New Report Dissects Ethics of Emerging Human Brain Cell Models
Amanda Heidt | Apr 12, 2021
The National Academies’ report touches on ethical issues raised by new technologies such as brain organoids and human-animal chimeras, and suggests that current regulatory oversight is sufficient.
The advantages of 3-D cell culture
The Advantages of 3-D Cell Culture
MilliporeSigma | Mar 29, 2022
3-D cell culture narrows the gap between in vitro and in vivo.
Organoids Repair Bile Ducts
Abby Olena | Feb 18, 2021
Researchers determined that when introduced into damaged mouse or donated human livers, these lab-grown tissues could integrate into bile ducts and function normally.
Gene-Edited Organoids Explore Neanderthal Brain Function
Jef Akst | Feb 12, 2021
Using CRISPR to swap an archaic variant of the NOVA1 gene into human stem cells, researchers create organoids with neurodevelopmental differences from those carrying modern DNA.
Human large intestine tissue under microscope view
Mini-Guts to the Rescue: Introducing 3-D Organoid Cell Cultures
The Scientist Creative Services Team, MilliporeSigma | Jan 19, 2022
A cost-effective 3-D organoid biobank provides a versatile translational research tool.
The Many Model Systems of COVID-19
Abby Olena | Nov 4, 2020
Researchers turn to familiar model animals, along with some fresh strategies, to develop countermeasures against SARS-CoV-2 and investigate the biology of infection.
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SARS-CoV-2 Can Infect Human Brain Organoids
Katarina Zimmer | Jul 9, 2020
The results are a proof-of-concept that the novel coronavirus can replicate in neurons, but it’s too soon to say whether this occurs in people with COVID-19.
Modeling the Complexity of Human Tumors in 3-D Cell Cultures
Modeling the Complexity of Human Tumors in 3-D Cell Cultures
The Scientist Creative Services Team | Dec 17, 2021
In this workshop, learn how to make precision medicine a reality by modeling human cancers in 3-D organoid cultures for drug screening.
Zika as Cancer Buster?
Amy Schleunes | Apr 1, 2020
By infecting glioblastoma cells but not healthy brain tissue, some form of the virus could serve a therapeutic purpose.
snake venom stem cells
Snake Venom Gland Organoids Produce Functional Toxins
Amy Schleunes | Jan 24, 2020
Stem cells from nine snake species respond to tissue culturing techniques previously used only on mouse and human stem cells.
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A New Model with Fully Functioning Blood Vessels Mimics Brain Cancer
Roni Dengler, PhD | Sep 10, 2021
A newly developed platform may one day replace cell culture and animal models to personalize cancer treatment.
Sergiu Pasca Builds Brains to Study Developmental Disease
Emily Makowski | Dec 1, 2019
The Stanford University professor helped develop a technique to grow brain organoids from induced pluripotent stem cells.
Organoids Don’t Accurately Model Human Brain Development
Diana Kwon | Oct 23, 2019
A new study suggests that growing in a stressful environment prevents “brains-in-a-dish” from growing in the same way as their in vivo counterparts.
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The Scientist Speaks - The Reality of Regenerative Medicine
The Scientist Creative Services Team | Aug 26, 2021
After decades of research the potential of regenerative medicine becomes a life-saving reality.
Image of the Day: Patient-Derived Organoids
Emily Makowski | Oct 10, 2019
Three-dimensional tissue cultures grown from cancer patients’ own tumors can predict responses to the drug irinotecan.
Opinion: Develop Organoids, Not Chimeras, for Transplantation
John D. Loike and Robert Pollack | Oct 1, 2019
Scientists are devising human-animal hybrids for harvesting human organs, but lab-derived mini-organs are a less ethically fraught solution to meeting the need for transplantation.
istock
How to Grow a Mouse Embryo in a Dish
Roni Dengler, PhD | Aug 3, 2021
Researchers are taking the concept of three-dimensional cell culture beyond single organoids to develop embryos from cells.
Human Cortical Organoids Model Neuronal Networks
Abby Olena | Aug 29, 2019
After growing in culture for a few months, the mini-brains produced rhythmic neural activity that strengthened over time.