Useful Construction

By Drew Endy FEATUREIs This Life?Useful Construction How to design a chassis for synthetic biological systems Drew Endy is an assistantprofessor in the biologicalengineering division andcofounder of MassachusettsInstitute of Technology's syntheticbiology working group.Creation implies an act that is based on some combinationof perfect

Written byDrew Endy
| 3 min read

Register for free to listen to this article
Listen with Speechify
0:00
3:00
Share

Creation implies an act that is based on some combinationof perfect knowledge, unlimited power, and infiniteresources. Gods create. Engineers on the other hand,from structural to electrical and now biological, arealways constrained by (1) an imperfect understandingof raw materials, (2) limited abilities to manipulate these materials,and (3) a budget. As a result, engineers construct. The art of engineeringis to reliably construct useful and beautiful artifacts despiteour limits.

In synthetic biology, there is now tremendous excitement aboutconstructing fully functioning cells from scratch. Unlike past scientificresearch - for example, sequencing of the human genome - the raceto construct synthetic cells has no finish line. Instead, synthetic cellswill be judged on their elegance of design, functional prowess, andsafety features, all characteristics that can be continuously improved.For comparison, would you want to drive your car across the world'sfirst "minimal" bridge?

As one or more of the remarkably diverse approaches toconstruct synthetic cells succeed, the resulting ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!
Already a member? Login Here

Meet the Author

Published In

Share
Image of a woman with her hands across her stomach. She has a look of discomfort on her face. There is a blown up image of her stomach next to her and it has colorful butterflies and gut bacteria all swarming within the gut.
November 2025, Issue 1

Why Do We Feel Butterflies in the Stomach?

These fluttering sensations are the brain’s reaction to certain emotions, which can be amplified or soothed by the gut’s own “bugs".

View this Issue
Olga Anczukow and Ryan Englander discuss how transcriptome splicing affects immune system function in lung cancer.

Long-Read RNA Sequencing Reveals a Regulatory Role for Splicing in Immunotherapy Responses

Pacific Biosciences logo
Research Roundtable: The Evolving World of Spatial Biology

Research Roundtable: The Evolving World of Spatial Biology

Conceptual cartoon image of gene editing technology

Exploring the State of the Art in Gene Editing Techniques

Bio-Rad
Conceptual image of a doctor holding a brain puzzle, representing Alzheimer's disease diagnosis.

Simplifying Early Alzheimer’s Disease Diagnosis with Blood Testing

fujirebio logo

Products

Eppendorf Logo

Research on rewiring neural circuit in fruit flies wins 2025 Eppendorf & Science Prize

Evident Logo

EVIDENT's New FLUOVIEW FV5000 Redefines the Boundaries of Confocal and Multiphoton Imaging

Evident Logo

EVIDENT Launches Sixth Annual Image of the Year Contest

10x Genomics Logo

10x Genomics Launches the Next Generation of Chromium Flex to Empower Scientists to Massively Scale Single Cell Research