Why You Should Be Annotating

Scientists who rely on accurate gene predictions should share in the burden of creating them

Written byJeffrey M. Perkel
| 3 min read

Register for free to listen to this article
Listen with Speechify
0:00
3:00
Share

Your local convenience store probably has a dish filled with pennies near the checkout. If your order costs $1.01 and you don't have a penny, you take one. The next time you're in, if you get change, you're expected to leave a penny. Unfortunately, when it comes to annotating sequence databases, it seems most researchers are the type to take a penny, but not give one back.

With the click of a mouse, scientists gain free access to enormously expensive and annotated sequence databases, the product of teams of researchers and informaticians. Yet when users notice errors in annotation - gene models that don't match their own data, for instance - they generally keep the knowledge to themselves. "There's a certain amount of apathy," says WormBase developer Lincoln Stein. "People realize a gene model is incorrect but they don't report it."

They don't alert database curators to new gene models ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!
Already a member? Login Here

Meet the Author

Published In

Share
Illustration of a developing fetus surrounded by a clear fluid with a subtle yellow tinge, representing amniotic fluid.
January 2026, Issue 1

What Is the Amniotic Fluid Composed of?

The liquid world of fetal development provides a rich source of nutrition and protection tailored to meet the needs of the growing fetus.

View this Issue
Skip the Wait for Protein Stability Data with Aunty

Skip the Wait for Protein Stability Data with Aunty

Unchained Labs
Graphic of three DNA helices in various colors

An Automated DNA-to-Data Framework for Production-Scale Sequencing

illumina
Exploring Cellular Organization with Spatial Proteomics

Exploring Cellular Organization with Spatial Proteomics

Abstract illustration of spheres with multiple layers, representing endoderm, ectoderm, and mesoderm derived organoids

Organoid Origins and How to Grow Them

Thermo Fisher Logo

Products

Brandtech Logo

BRANDTECH Scientific Introduces the Transferpette® pro Micropipette: A New Twist on Comfort and Control

Biotium Logo

Biotium Launches GlycoLiner™ Cell Surface Glycoprotein Labeling Kits for Rapid and Selective Cell Surface Imaging

Colorful abstract spiral dot pattern on a black background

Thermo Scientific X and S Series General Purpose Centrifuges

Thermo Fisher Logo
Abstract background with red and blue laser lights

VANTAstar Flexible microplate reader with simplified workflows

BMG LABTECH