Pulse Oximeter

Making Your Case
Making Your Case
How to avoid the biggest presentations mistakes.
Making Your Case
Making Your Case
How to avoid the biggest presentations mistakes.
Can You Go Home Again?
Can You Go Home Again?
Going from academia to business - and back again - is no easy feat. The exceptions not only prove the rule, but also that it can be done.
ROUNDUP
ROUNDUP
Ain't Misbehavin'?
ROUNDUP
ROUNDUP
Killer App: Microsoft Bio?
ROUNDUP
ROUNDUP
Multiple PIs

Contributors

CONTRIBUTORS
CONTRIBUTORS
Harold Varmus is president of the Memorial Sloan-Kettering Cancer Center since 2000, and took the position after serving for more than six years as director of the NIH. The 1989 Nobel Prize winner is also a cofounder of the Public Library of Science and a member of the Science Initiative Group (SIG). On page 24, he makes the case for Global Science Corps, a SIG program that aims to place well-trained scientists and engineers in the research centers of developing countries to collab

Editorial

The Elephant Man and the Art of Jigsaw Puzzles
The Elephant Man and the Art of Jigsaw Puzzles
Talk of systems biology has a way of drifting, quite rapidly, into the abstract. I'm reminded of the preamble to Georges Perec's complex but engaging novel, Life, A User's Manual."The art of jigsaw puzzles seems of little substance, easily exhausted, wholly dealt with by a basic introduction to Gestalt: The perceived object... is not a sum of elements to be distinguished from each other and analyzed discreetly, but a pattern, that is to say a form, a structure... knowl

Letter

Letters
Letters
A new type of cancer cell growthRe: cancer stem cells.1,2 Recently we have reported a novel type of cell division involved in the origin and growth of cancers.3,4 Termed neosis, this type of cell division occurs only in senescent polyploid giant cells and never in normal diploid cells. Up to 10% of tumor cells both in vitro and in vivo are polyploid, and so far there is no explanation of their role in cancer. These resemble senescent cells, which are thought to be part of the tumor

Notebook

Cockroaches: Nature's petri dish
Cockroaches: Nature's petri dish
Credit: © COURTESY OF THE CDC" /> Credit: © COURTESY OF THE CDCIf the sight of a cockroach scuttling across your kitchen floor is enough to trigger paroxysms of disgust, then you'd be well advised to take a deep breath before browsing through "Cockroaches in the Home, Cockroaches Everywhere!!!" This exceptionally well-named publication was written by a team led by Sesai Mpuchane, associate professor of biological sciences at the University of Botswana, and it is meant to be scar
Science pen pals
Science pen pals
Credit: COURTESY OF THE J. DAVID GLADSTONE INSTITUTES" /> Credit: COURTESY OF THE J. DAVID GLADSTONE INSTITUTESLast spring, Sue Saunders was writing a grant proposal for the elementary school where she runs an after-school literacy program, when a conversation with her daughter Laura, a postdoc studying cancer biology at the J. David Gladstone Institutes, gave her an idea.Every month, Laura and a few fellow postdocs had been visiting Junipero Serra Elementary School in Bernal
The task of keeping elephants
The task of keeping elephants
Credit: © WILLIAM LORENZ" /> Credit: © WILLIAM LORENZ The adult African elephant (Loxodonta africana) eats between 150 and 170 kilograms of food and drinks as much as 200 liters of water every day. Now imagine keeping 7,000 of those animals fed.That's the task of the staff at Kruger National Park, a 2-million hectare reserve that stretches 350 kilometers along South Africa's border with Mozambique. The elephant's appetite has an enormous impact on the surrounding envi
An interview goes up in smoke
An interview goes up in smoke
Credit: © DIEGO CERVO" /> Credit: © DIEGO CERVO Picture this: Among the cirque du swag of the BIO 2006 exhibit hall in Chicago, a cheerful young scientist pads up to the booth of a certain magazine of the life sciences. On scanning her nametag, one of my colleagues notices an interesting affiliation: Philip Morris. Intrigued, my colleague asks the senior research scientist about her work, which she says involves "harm reduction."With 16,000 people in attendance, BIO
Mumps in seat 21C!
Mumps in seat 21C!
As SARS emerged in 2003, attention quickly turned to airplanes, the most likely source of international spread. At the time, the US Centers for Disease Control and Prevention (CDC) received passenger manifests, usually in hard copy, to notify people who had shared a flight with someone later diagnosed with the infection.In the Internet age, that procedure was hardly ideal. "The paper management of data was problematic," says the CDC's Christie Reed, mainly because of the di

The Agenda

THE AGENDA
THE AGENDA
HIV'S ANNIVERSARY >> June 5 marks 25 years since the disease now known as AIDS was first reported (see p. 36), but it was only 51 years ago that researchers first dissected a virus into its constituent parts and put it back together. On June 10, 1955, Heinz L. Fraenkel-Conrat and Robley Williams at the Virus Laboratory of the University of California at Berkeley reported the deconstruction and reconstitution of the tobacco mosaic virus, demonstrating that RNA serves as its genetic materi

Opinion

Time for a Global Science Corps
Time for a Global Science Corps
Spend a year in a lab in a developing country, and build scientific capacity around the world

Column

The Three Worst Places to Be a Postdoc
The Three Worst Places to Be a Postdoc
When choosing postgraduate training, senior faculty aren't always the best mentors
We Have Met the Enemy, and He Is Us
We Have Met the Enemy, and He Is Us
What infectious disease says about humanity's penchant for self-destruction!

Uncategorized

Are You Listening
Are You Listening
FEATUREPodcasts   Illustrations by John MacNeill For some, science podcasts are time-savers that open their minds to new fields. For others, they're just another fad. What's the future? BY ISHANI GANGULISeventy-three-year-old Franklin Leach, professor emeritus of biochemistry and molecular biology at Oklahoma State University, was nearing the last leg of his daily neighborhood walk when he first heard that private medical in
8 Reasons to Tune In
8 Reasons to Tune In
FEATUREPodcast 8 Reasons to Tune InBY ISHANI GANGULIILLUSTRATIONS BY JOHN MACNEILLThough the Top 25 podcast lists are still dominated by the likes of MTV and Dave Chappelle, science podcasts are coming into their own as journals, magazines, and radio shows throw their contributions into the mix. Here are eight that are worth checking out, and what our respondents think of them. For a more comprehensive listing of s
A science podcaster bares all
A science podcaster bares all
FEATUREPodcast   A science podcaster bares allBY ISHANI GANGULIILLUSTRATIONS BY JOHN MACNEILLChris Smith isn't afraid to shed a little clothing in the name of science. A clinician and Cambridge virology lecturer by day, he moonlights as a popular radio personality turned podcaster: the original Naked Scientist and the voice behind the Nature podcast.It all began at a Cambridge science festival in early 1999, whe
Podcasts go to school
Podcasts go to school
FEATUREPodcast   Podcasts go to schoolBY ISHANI GANGULIILLUSTRATIONS BY JOHN MACNEILLJustin Gallivan was starting off the fall 2005 semester with his biochemistry course at Emory University in Atlanta when he noticed the front row of desks was covered with tape recorders and microphone-equipped iPods that students had brought to record his lecture. One coed even posted to the class website, offering five dol
The Scientist's Guide to Science Podcasts
The Scientist's Guide to Science Podcasts
FEATUREPodcast   The Scientist's Guide to Science PodcastsARTICLE EXTRASRelated Articles: Are You Listening?For some, science podcasts are time-savers that open their minds to new fields. For others, they're just another fad. What's the future? 8 Reasons to Tune InA science podcaster bares allPodcasts go to schoolAbsolute Sciencewww.welltopia.com/All in the Mind www.abc.net.au/rn/allinthe
25 Years with HIV
25 Years with HIV
FEATURE25 Years with HIV BY PHILIP COHENARTICLE EXTRAS Feature ArticleThe Elite Controllers of HIVGAIL DUTTON reports from San Francisco on how infected nonprogressors - also known as elite controllers - are providing clues to the control, and potentially the eradication, of HIV. Related Articles: Jeff Getty: Lessons in desperate measuresHow a risky experiment led to a new understanding of HIV HIV Shows ItselfA 1981 report in
HIV Shows Itself
HIV Shows Itself
A 1981 report in the MMWR marks the beginning
The Impact of HIV
The Impact of HIV
Its progression, 1981-2006 and beyond
The Long Journey Home
The Long Journey Home
FEATUREScience in Africa ALL PHOTOS BY STEPHEN PINCOCK Is African Science - Long Plagued by a Lack of Equipment and Resources - Poised for a Comeback? BY STEPHEN PINCOCKARTICLE EXTRASRelated Articles: Why we must re-educate African Science Moving African science forwardAn continent-wide framework is necessary, argues an advisor to the New Partnership for
Why we must re-educate African science
Why we must re-educate African science
FEATUREScience in Africa Why we must re-educate African scienceBY KAZHILA CHINSEMBUARTICLE EXTRASRelated Articles: The Long Journey HomeIs African Science - Long Plagued by a Lack of Equipment and Resources - Poised for a Comeback? Moving African science forwardAn continent-wide framework is necessary, argues an advisor to the New Partnership for Africa's DevelopmentWhen will Africa produce a Nobel
Moving African science forward
Moving African science forward
FEATUREScience in Africa   Moving African science forwardAn continent-wide framework is necessary, argues an advisor to the New Partnership for Africa's DevelopmentBY JOHN MUGABEARTICLE EXTRASRelated Articles: The Long Journey HomeIs African Science - Long Plagued by a Lack of Equipment and Resources - Poised for a Comeback?Why we must re-educate African ScienceTo succeed in its aspirations of
Systems Biology: Beyond the Buzz
Systems Biology: Beyond the Buzz
FEATURESystems Biology Ā© THOM GRAVES Lessons from EGFR research show how to kick-start a systems approach for other areas of biology BY H. STEVEN WILEYARTICLE EXTRASInfographic: Seeing EGFR from a Systems PerspectiveIf you want to start an interesting debate at almost any scientific meeting, just bring up systems biology. Latched onto by the scientific and even

Profile

How Bacteria Talk
How Bacteria Talk
It's a good thing "rock star of microbiology" Bonnie Bassler didn't end up studying cancer

Hot Paper

So Much Diversity, Such Little Cells
So Much Diversity, Such Little Cells
Comparative yeast genomics reveals mechanisms of genome evolution

Books etc.

Lipid Rafts' Failure to Launch
Lipid Rafts' Failure to Launch
Debating what binds membrane microdomains
PAPERS TO WATCH
PAPERS TO WATCH
Cell division rewinds
PAPERS TO WATCH
PAPERS TO WATCH
Untangling nucleolar networks
Papers to Watch
Papers to Watch
B.F. Voight et al., "A map of recent positive selection in the human genome," PLoS Biol, 4:e72, March 2006.Based on the combination of Linkage Disequalibrium with allele frequency in three human populations, ... the authors discovered recent alleles that probably provided selective advantages to their possessors in adapting to different environmental conditions imposed on the three populations since they separated approximately 100,000 years ago.Ueli SchiblerUniversity of
SCIENTIST TO WATCH
SCIENTIST TO WATCH
Helen Blackwell: The Accidental Microbiologist

Lab Tools

Why You Should Be Annotating
Why You Should Be Annotating
Scientists who rely on accurate gene predictions should share in the burden of creating them
Upgrade Your Lab to TIRF
Upgrade Your Lab to TIRF
Why spend six figures on a new total internal reflection fluorescence system when you can upgrade your existing microscope for just $30,000?

How It Works

TIRF Microscopy
TIRF Microscopy
/article/flash/23556/1/Click to view enlarged diagram Credit: ILLUSTRATION: ANDREW MEEHAN/ACKNOWLEDGEMENT: MICHAEL DAVIDSON" />/article/flash/23556/1/Click to view enlarged diagram Credit: ILLUSTRATION: ANDREW MEEHAN/ACKNOWLEDGEMENT: MICHAEL DAVIDSONStick a soda straw into a glass of water, and from the side, the straw will appear to bend at the interface between air and water. That effect is caused by the different refractive indexes of the air and water, which causes the li

BioBusiness

Biotechs AIM for Alternative Financing
Biotechs AIM for Alternative Financing
London's lesser-known stock exchange offers the possibility of money for hungry biotechs
Making Ethics Fit
Making Ethics Fit
How companies are integrating ethics into their core foundation
THE ROUNDUP
THE ROUNDUP
Biosimilars: Europe Says Yes
THE ROUNDUP
THE ROUNDUP
FDA Seeks 'Little' Information

Foundations

The Discovery of Reverse Transcriptase
The Discovery of Reverse Transcriptase
Credit: COURTESY OF DAVID BALTIMORE" /> Credit: COURTESY OF DAVID BALTIMOREIn the spring of 1970 two young investigators shook the foundations of molecular biology's "central dogma," which holds that DNA is transcribed to RNA, which in turn is translated into protein.David Baltimore, then a 32-year-old virologist at the Massachusetts Institute of Technology, was studying RNA viruses, trying to understand how they replicate their genomes. Hypothesizing the presence of a virus-assoc