Harold Varmus is president of the Memorial Sloan-Kettering Cancer Center since 2000, and took the position after serving for more than six years as director of the NIH. The 1989 Nobel Prize winner is also a cofounder of the Public Library of Science and a member of the Science Initiative Group (SIG). On page 24, he makes the case for Global Science Corps, a SIG program that aims to place well-trained scientists and engineers in the research centers of developing countries to collab
Talk of systems biology has a way of drifting, quite rapidly, into the abstract. I'm reminded of the preamble to Georges Perec's complex but engaging novel, Life, A User's Manual."The art of jigsaw puzzles seems of little substance, easily exhausted, wholly dealt with by a basic introduction to Gestalt: The perceived object... is not a sum of elements to be distinguished from each other and analyzed discreetly, but a pattern, that is to say a form, a structure... knowl
A new type of cancer cell growthRe: cancer stem cells.1,2 Recently we have reported a novel type of cell division involved in the origin and growth of cancers.3,4 Termed neosis, this type of cell division occurs only in senescent polyploid giant cells and never in normal diploid cells. Up to 10% of tumor cells both in vitro and in vivo are polyploid, and so far there is no explanation of their role in cancer. These resemble senescent cells, which are thought to be part of the tumor
Credit: COURTESY OF THE J. DAVID GLADSTONE INSTITUTES" /> Credit: COURTESY OF THE J. DAVID GLADSTONE INSTITUTESLast spring, Sue Saunders was writing a grant proposal for the elementary school where she runs an after-school literacy program, when a conversation with her daughter Laura, a postdoc studying cancer biology at the J. David Gladstone Institutes, gave her an idea.Every month, Laura and a few fellow postdocs had been visiting Junipero Serra Elementary School in Bernal
As SARS emerged in 2003, attention quickly turned to airplanes, the most likely source of international spread. At the time, the US Centers for Disease Control and Prevention (CDC) received passenger manifests, usually in hard copy, to notify people who had shared a flight with someone later diagnosed with the infection.In the Internet age, that procedure was hardly ideal. "The paper management of data was problematic," says the CDC's Christie Reed, mainly because of the di
HIV'S ANNIVERSARY >> June 5 marks 25 years since the disease now known as AIDS was first reported (see p. 36), but it was only 51 years ago that researchers first dissected a virus into its constituent parts and put it back together. On June 10, 1955, Heinz L. Fraenkel-Conrat and Robley Williams at the Virus Laboratory of the University of California at Berkeley reported the deconstruction and reconstitution of the tobacco mosaic virus, demonstrating that RNA serves as its genetic materi
FEATUREPodcasts Illustrations by John MacNeill For some, science podcasts are time-savers that open their minds to new fields. For others, they're just another fad. What's the future? BY ISHANI GANGULISeventy-three-year-old Franklin Leach, professor emeritus of biochemistry and molecular biology at Oklahoma State University, was nearing the last leg of his daily neighborhood walk when he first heard that private medical in
FEATUREPodcast 8 Reasons to Tune InBY ISHANI GANGULIILLUSTRATIONS BY JOHN MACNEILLThough the Top 25 podcast lists are still dominated by the likes of MTV and Dave Chappelle, science podcasts are coming into their own as journals, magazines, and radio shows throw their contributions into the mix. Here are eight that are worth checking out, and what our respondents think of them. For a more comprehensive listing of s
FEATUREPodcast A science podcaster bares allBY ISHANI GANGULIILLUSTRATIONS BY JOHN MACNEILLChris Smith isn't afraid to shed a little clothing in the name of science. A clinician and Cambridge virology lecturer by day, he moonlights as a popular radio personality turned podcaster: the original Naked Scientist and the voice behind the Nature podcast.It all began at a Cambridge science festival in early 1999, whe
FEATUREPodcast Podcasts go to schoolBY ISHANI GANGULIILLUSTRATIONS BY JOHN MACNEILLJustin Gallivan was starting off the fall 2005 semester with his biochemistry course at Emory University in Atlanta when he noticed the front row of desks was covered with tape recorders and microphone-equipped iPods that students had brought to record his lecture. One coed even posted to the class website, offering five dol
FEATUREPodcast The Scientist's Guide to Science PodcastsARTICLE EXTRASRelated Articles: Are You Listening?For some, science podcasts are time-savers that open their minds to new fields. For others, they're just another fad. What's the future? 8 Reasons to Tune InA science podcaster bares allPodcasts go to schoolAbsolute Sciencewww.welltopia.com/All in the Mind www.abc.net.au/rn/allinthe
FEATURE25 Years with HIV BY PHILIP COHENARTICLE EXTRAS Feature ArticleThe Elite Controllers of HIVGAIL DUTTON reports from San Francisco on how infected nonprogressors - also known as elite controllers - are providing clues to the control, and potentially the eradication, of HIV. Related Articles: Jeff Getty: Lessons in desperate measuresHow a risky experiment led to a new understanding of HIV HIV Shows ItselfA 1981 report in
FEATUREScience in Africa ALL PHOTOS BY STEPHEN PINCOCK Is African Science - Long Plagued by a Lack of Equipment and Resources - Poised for a Comeback? BY STEPHEN PINCOCKARTICLE EXTRASRelated Articles: Why we must re-educate African Science Moving African science forwardAn continent-wide framework is necessary, argues an advisor to the New Partnership for
FEATUREScience in Africa Why we must re-educate African scienceBY KAZHILA CHINSEMBUARTICLE EXTRASRelated Articles: The Long Journey HomeIs African Science - Long Plagued by a Lack of Equipment and Resources - Poised for a Comeback? Moving African science forwardAn continent-wide framework is necessary, argues an advisor to the New Partnership for Africa's DevelopmentWhen will Africa produce a Nobel
FEATUREScience in Africa Moving African science forwardAn continent-wide framework is necessary, argues an advisor to the New Partnership for Africa's DevelopmentBY JOHN MUGABEARTICLE EXTRASRelated Articles: The Long Journey HomeIs African Science - Long Plagued by a Lack of Equipment and Resources - Poised for a Comeback?Why we must re-educate African ScienceTo succeed in its aspirations of
B.F. Voight et al., "A map of recent positive selection in the human genome," PLoS Biol, 4:e72, March 2006.Based on the combination of Linkage Disequalibrium with allele frequency in three human populations, ... the authors discovered recent alleles that probably provided selective advantages to their possessors in adapting to different environmental conditions imposed on the three populations since they separated approximately 100,000 years ago.Ueli SchiblerUniversity of
/article/flash/23556/1/Click to view enlarged diagram Credit: ILLUSTRATION: ANDREW MEEHAN/ACKNOWLEDGEMENT: MICHAEL DAVIDSON" />/article/flash/23556/1/Click to view enlarged diagram Credit: ILLUSTRATION: ANDREW MEEHAN/ACKNOWLEDGEMENT: MICHAEL DAVIDSONStick a soda straw into a glass of water, and from the side, the straw will appear to bend at the interface between air and water. That effect is caused by the different refractive indexes of the air and water, which causes the li
Credit: COURTESY OF DAVID BALTIMORE" /> Credit: COURTESY OF DAVID BALTIMOREIn the spring of 1970 two young investigators shook the foundations of molecular biology's "central dogma," which holds that DNA is transcribed to RNA, which in turn is translated into protein.David Baltimore, then a 32-year-old virologist at the Massachusetts Institute of Technology, was studying RNA viruses, trying to understand how they replicate their genomes. Hypothesizing the presence of a virus-assoc
