Systems Biology: Beyond the Buzz

FEATURESystems Biology © THOM GRAVES Lessons from EGFR research show how to kick-start a systems approach for other areas of biology BY H. STEVEN WILEYARTICLE EXTRASInfographic: Seeing EGFR from a Systems PerspectiveIf you want to start an interesting debate at almost any scientific meeting, just bring up systems biology. Latched onto by the scientific and even

Written byH. Steven Wiley
| 10 min read

Register for free to listen to this article
Listen with Speechify
0:00
10:00
Share

Lessons from EGFR research show how to kick-start a systems approach for other areas of biology

If you want to start an interesting debate at almost any scientific meeting, just bring up systems biology. Latched onto by the scientific and even the lay press as the "next big thing," it is clear that many scientists have misgivings about the subject. The rapidly changing landscape of biology is an exciting notion but one that can be worrisome. Regarded by some as little more than a buzzword and others as the next step in bringing biology from a descriptive to a predictive science, systems biology is host to disagreements fueled in part by a lack of a uniform definition.

At the most basic level, systems biology seeks to understand how the molecular processes of cells are linked to higher biological functions. The relationships between low- and high-level functions must be specified to ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!
Already a member? Login Here

Meet the Author

Published In

Share
February 2026

A Stubborn Gene, a Failed Experiment, and a New Path

When experiments refuse to cooperate, you try again and again. For Rafael Najmanovich, the setbacks ultimately pushed him in a new direction.

View this Issue
Human-Relevant In Vitro Models Enable Predictive Drug Discovery

Advancing Drug Discovery with Complex Human In Vitro Models

Stemcell Technologies
Redefining Immunology Through Advanced Technologies

Redefining Immunology Through Advanced Technologies

Ensuring Regulatory Compliance in AAV Manufacturing with Analytical Ultracentrifugation

Ensuring Regulatory Compliance in AAV Manufacturing with Analytical Ultracentrifugation

Beckman Coulter Logo
Conceptual multicolored vector image of cancer research, depicting various biomedical approaches to cancer therapy

Maximizing Cancer Research Model Systems

bioxcell

Products

Sino Biological Logo

Sino Biological Pioneers Life Sciences Innovation with High-Quality Bioreagents on Inside Business Today with Bill and Guiliana Rancic

Sino Biological Logo

Sino Biological Expands Research Reagent Portfolio to Support Global Nipah Virus Vaccine and Diagnostic Development

Beckman Coulter

Beckman Coulter Life Sciences Partners with Automata to Accelerate AI-Ready Laboratory Automation

Refeyn logo

Refeyn named in the Sunday Times 100 Tech list of the UK’s fastest-growing technology companies