True understanding of the complexity of biological systems demands an assortment of model systems.

Judiciously applied pressure could benefit the scientific system by providing an opportunity for renewal.

More collaborators and more data are the key ingredients.

Novel observations can sometimes be correct for unexpected reasons.

Measuring how individual cells differ from each other will enhance the predictive power of biology.

Learning community skills from microbes

By H. Steven Wiley If Bacteria Can Do It… Learning community skills from microbes Andrzej Krauze One of the greatest joys of being a scientist is continuously having the opportunity to see the world in new ways. At a national laboratory or research university, you’re exposed to many different fields of research, from which you can always glean something useful. My current fascination is learning about microbial communities and how they thrive by achi

Data standards need to be introduced—now.

By H. Steven Wiley At the Tipping Point Data standards need to be introduced—now. Andrzej Krauze There comes a time in every field of science when things suddenly change. While it might not be immediately apparent that things are different, a tipping point has occurred.Biology is now at such a point. The reason is the introduction of high-throughput genomics-based technologies. I am not talking about the consequences of the sequencing of the human g

By H. Steven Wiley One of the Good Guys Being someone who shares cell lines and reagents can be more satisfying than being a famous PI at a major lab. Small scientific conferences are great if you enjoy learning. You can take in the latest advances in your field during the scientific sessions and then hear about how your colleagues are doing afterwards—generally over a beer. I was having a particularly good time with some younger colleagues at a meeting las

By H. Steven Wiley Scientists vs. Engineers One prefers the unknown, the other can’t stand it. Now more than ever, we have to find a way to get along. We are starting to get to a point where the engineering sciences can make a real impact on our progress. In the past, I have heard there was conflict between the “two cultures” of science and the humanities. I don’t see a lot of evidence for that type of conflict today, mostly because my

By H. Steven Wiley Think Outside the Bio-Box We like to complain, but it’s a great time to be a biologist—as long as you don’t just think about academia. The idea that having a position at a research university is the best job possible is specious. A recent article in the Wall Street Journal listed the best jobs in America, based on their associated work environment, income, hiring outlook, physical demands, and stress factors. Biologist w

By H. Steven Wiley Keep it Simple Telling a simple story about your data is the easiest way to get funded—and it’s one of the hardest things to do. The big and simple stories attract ample funding and top scientific talent, whereas the complex stories remain mostly ignored in specialty journals. One common piece of advice I frequently give to young scientists is to always tell a story with their data, because it’s a us

FEATURESystems Biology © THOM GRAVES Lessons from EGFR research show how to kick-start a systems approach for other areas of biology BY H. STEVEN WILEYARTICLE EXTRASInfographic: Seeing EGFR from a Systems PerspectiveIf you want to start an interesting debate at almost any scientific meeting, just bring up systems biology. Latched onto by the scientific and even