Copyright (c)2000 by the American Society for Clinical Investigation The crystal structure of AMP-PNP bound to Lck was used to make a model of the Abl kinase domain. Left, the general architecture of the Abl kinase domain; top right, topology of the ATP-binding cleft of the Abl protein kinase; bottom right, amino acid side chains lining the APT-binding cleft. "I feel so good that sometimes I forget I have leukemia," writes Gay Bratton of her experience with STI571, Novartis Pharma's experimenta
| Copyright (c)2000 by the American Society for Clinical Investigation |
 The crystal structure of AMP-PNP bound to Lck was used to make a model of the Abl kinase domain. Left, the general architecture of the Abl kinase domain; top right, topology of the ATP-binding cleft of the Abl protein kinase; bottom right, amino acid side chains lining the APT-binding cleft. |
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