"There is poor feeding at birth, and then subtle developmental delay between 3 and 6 months," says William Dobyns, a professor of human genetics at the University of Chicago. The course rapidly worsens. "These kids live to about age 5 to 6, they are severely mentally retarded and have intractable seizures," adds Guy Caldwell, assistant professor of biological sciences at the University of Alabama in Tuscaloosa.
Caldwell and graduate student Shelli Williams identified a mutation in the worm's version of the lissencephaly gene. The animal convulses