In the late 1970s, researchers who wanted to quantify the results of new immunoprecipitation assays, such as ELISA, had three choices: risk human error and a headache by using a manual reader, break out the cuvets and the spectrophotometer, or pay as much as $15,000 for a bulky automated reader.
In 1981, Winooski, Vt.-based, BioTek Instruments, introduced the EL307. Roughly the size of a toaster oven, the EL307 combined the ease of automated microplate reading with the low cost of the manual readers. Users still had to reposition their 96-well microplates by hand, but a spring-loaded device and magnets made this process easier than with purely manual readers. The EL307, shown here in a BioTek pamphlet from 1984—1985, was also directly connected to a printer that simultaneously recorded results from each well, eliminating the need to manually record each well's location. It took a mere three minutes to produce results ...
