Courtesy of Gabriel Nuñez
AND NOW PRESENTING: In this model, microorganisms phagocytosed by the antigen presenting cell (left) release ligands recognized by NOD/CARD proteins and peptides that associate with MHC class II molecules. Recognition of intracellular ligands by NOD/CARD proteins and extracellular ligands by Toll-Like Receptors (TLRs) mediates NF-kB activity. These intracellular events induce cytokine secretion and antigen presentation, as well as the expression of co-stimulatory molecules.

It's rare in this feature to highlight a researcher's work twice in the same year, because it is rare for a researcher to achieve what Gabriel Nuñez's team at the University of Michigan, Ann Arbor, has accomplished. Besides generating at least three Hot Papers on NOD1 and NOD2 in a matter of a few months,1-3 Nuñez helped create the discipline of intracellular pathogen recognition, and influenced the work of scientists in fields as diverse as genetics, innate and mucosal immunity, gastroenterology, and...

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