Further establishing its position as an innovator in tools for detection of neurodegenerative diseases, Enzo offers a high sensitivity APP ΔC31 ELISA Kit; a one-of-a-kind quantitative ELISA for Alzheimer’s research.
Unlike the more familiar β-amyloid and tau fibrillar pathway leading to amyloid plaques and tangles, APP ΔC31 reveals an alternative, unique pro-apoptotic mechanism leading to Alzheimer’s disease. APP ΔC31 is the stable amyloid precursor protein fragment created from a caspase cleavage event of the APP695 molecule at Asp664 leaving a smaller 31-residue intracellular fragment. Both the APP ΔC31 and 31-residue fragments are pro-apoptotic and are present in 4-fold greater levels in Alzheimer’s disease patients [Bredesen D.E., et al. (2006) Nature, 443: 796-802]. Given that the smaller 31-residue fragment has a short half-life and is difficult to measure, the use of this APP ΔC31 ELISA provides for the first time a sensitive research and clinical tool to measure the levels of ...
