BY RON MAGOLDA
Medical Products Department
E.I. du Pont de Nemours & Co.
Wilmington, Del.
" Understanding enzyme mechanisms is of critical importance to the design of enzyme inhibitors. Conveniently located in the same journal issue, two new articles offer detailed and complementary approaches to this fundamental problem in bioorganic chemistry.
B.W. Matthews, “Structural basis of the action of thermolysin and related zinc peptidases,” Accounts of Chemical Research, 21 (9), 333-40, September 1988.
J.V. Schloss, “Significance of slow-binding enzyme inhibition and its relationship to reaction-intermediate analogs,” Accounts of Chemical Research, 21 (9), 348-53, September 1988.
" The search for sequence selective cleavage of DNA and RNA has been the focal point of intense investigation in molecular biology. A pair of papers provides very clever methods to perform this task ina potential catalytic fashion.
R.N. Zuckermann, PG. Schultz, “A hybrid sequence-selective ribonuclease 5,” Journal of the American Chemical Society, 110 (19), ...
