Articles by Ron Magolda

CHEMISTRY BY RON MAGOLDA Medical Products Department E.I. Du Pont de Nemours & Co. Wilmington, Del. " Rather than using triple-helix formation and DNA-binding proteins, a new approach is discussed that can sequence specifically cleaved supercoiled double-stranded DNAs by a hybrid nuclease utilizing D-loop formation. This design technology should facilitate the manipulation and mapping of genetic DNA. D.R. Corey, D. Pei, P.G. Schulz, "Sequence-selective hydrolysis of duplex DNA by an oligonuc

CHEMISTRY BY RON MAGOLDA Medical Products Department E.I. DuPont de Nemnours & Co. Wilmington, Del. " Ortho lithiation is a major tool inorganic synthesis A recent report extends this powerful technology to include magnesium counter ions, which offer several advantages. R.E. Eaton, C.-H. Lee, Y. Xiong, “Magnesium amide bases and amido-grignards. 1. Ortho magnesiation,” Journal of the American Chemical Society, 111, 80 16-18, 27 September 1989. (University of Chicago, Ill.) " A ne

CHEMISTRY BY RON MAGOLDA Medical Products Department E.I. Du Pont de Nemours & Co. Wilmington, Del. G-binding proteins have been implicated in a variety of biological processes. A structural analysis of this interesting class of proteins has been presented. P.Woolley, B.F.C. Clark, “Homologies in the structures of G-binding proteins: an analysis based on elongation factor EF-Tu,” BioTechnology, 7, 9 13-20, September 1989. (Aarhus University, Arhus, Denmark). The biosynthesis of

CHEMISTRY BY RON MAGOLDA Medical Products Department E.I. du Pont de Nemours & Co. Wilmington, Del. " A new and general route to pyridones is reported via an Aza-Robinson annulation. F.G. Fang, M. Prato, G. Kim, S.J. Danishefsky, “The Aza-Robinson annulation: an application to the synthesis of ISO-A58365A,” Tetrahedron Letters, 30, 3625-8, 1989. (Yale University, New Haven, Conn.) An exceptionally mild, efficient, and safe intramolecular method for the preparation of cyclopropa

CHEMISTRY BY RON MAGOLDA Medical Products Department E.I. du Pont de Nemours & Co. Wilmington, Del. A highly convergent and efficient route to the synthetically useful dihydropyrancarboxylates has been identified. L.F Tietze, H. Meier, H. Nutt, “The tandem Knoevenagel hetero Diels-Alder reaction with a formylacetic acid equivalent. Synthesis of dihydropyrancarboxylates,” Chemische Berichte, 122, 643-50, April 1989. (Institut für Organische Chemie der Universität Gottin

CHEMISTRY BY RON MAGOLDA Medical Products Department E.I. DuPont de Nemours & Co Wilmington, Del " A recent paper proposes DNA recombination to proceed via branched DNA molecules. The researchers used site-specific probes to understand the interactions. Q. Guo, N.C. Seeman, N.R. Kallenbach, “Site-specific interaction of intercalating drugs with a branched DNA molecule,”Biochemistry, 28, 2355-9, 21 March 1989. (New York University, New York) A structural analysis of the interact

CHEMISTRY BY RON MAGOLDA Medical Products Department E.I. duPont de Nemours & Co. Wilmington, DeL " This publication describes the first total synthesis of the potent immunosuppressant, (-)-FK-506. T.K. Jones, 5.0. Mills, R.A. Reamer, D. Askin, et al, “Total synthesis of the immunosuppressant (-)-FK-506,” Journal of American Chemical Society Ul (3), 1157-1159, February 1, 1989. ( Alanine racemase, a pyridoxal 5’-phosphate containing enzyme, has been inhibited with a number

CHEMISTRY BY RON MAGOLDA Medical Products Department E.I. du Pont de Nemours & Co. Wilmington, Del. " Strategies to control H1V-1 replication are being intensively investigated. A promising approach has been described using oligonucleoside phosphoramidates and phosphorothioates as antivitral agents. S. Argawal, J. Goodchild, M.P. Civeira, A.H. Thornton, P.S. Sam, P.C. Zamecnik, "Oligonucleoside phosphoramidates and phosphorothiostes as inhibitors of human immunodeficiency virus," Proceeding

CHEMISTRY BY RON MAGOLDA Medical Products Department E.I. du Pont de Nemours & Co. Wilmington, Del. " Understanding enzyme mechanisms is of critical importance to the design of enzyme inhibitors. Conveniently located in the same journal issue, two new articles offer detailed and complementary approaches to this fundamental problem in bioorganic chemistry. B.W. Matthews, “Structural basis of the action of thermolysin and related zinc peptidases,” Accounts of Chemical Research, 21 (