ATP is key taste messenger

New evidence discredits previous assumptions that assigned the role to serotonin

| 2 min read

Register for free to listen to this article
Listen with Speechify
0:00
2:00
Share

Adenosine triphosphate (ATP) has outshined serotonin as the most likely key neurotransmitter passing on the sense of taste from taste bud cells to primary afferent gustatory nerve fibers, researchers report in this week's issue of Science.

"It's the first time that we are able to find, at the level of these synapses, a substance that fills all the criteria of a neurotransmitter," co-author Leslie Stone, from Colorado State University in Fort Collins, Co., told The Scientist. "This doesn't rule out the involvement of serotonin or other substances in the taste bud, we just believe they're acting at another level, probably in the crosstalk between cells."

The cellular and molecular mechanisms of how chemical stimuli -- such as sugars, acids, and salts -- are converted into electrical signals are still widely unknown. Taste cells communicate with themselves through chemical and electric synapses, and some also communicate with nerves afferent to the ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member? Login Here

Meet the Author

  • Clementine Wallace

    This person does not yet have a bio.
Share
Image of a woman in a microbiology lab whose hair is caught on fire from a Bunsen burner.
April 1, 2025, Issue 1

Bunsen Burners and Bad Hair Days

Lab safety rules dictate that one must tie back long hair. Rosemarie Hansen learned the hard way when an open flame turned her locks into a lesson.

View this Issue
Conceptual image of biochemical laboratory sample preparation showing glassware and chemical formulas in the foreground and a scientist holding a pipette in the background.

Taking the Guesswork Out of Quality Control Standards

sartorius logo
An illustration of PFAS bubbles in front of a blue sky with clouds.

PFAS: The Forever Chemicals

sartorius logo
Unlocking the Unattainable in Gene Construction

Unlocking the Unattainable in Gene Construction

dna-script-primarylogo-digital
Concept illustration of acoustic waves and ripples.

Comparing Analytical Solutions for High-Throughput Drug Discovery

sciex

Products

Green Cooling

Thermo Scientific™ Centrifuges with GreenCool Technology

Thermo Fisher Logo
Singleron Avatar

Singleron Biotechnologies and Hamilton Bonaduz AG Announce the Launch of Tensor to Advance Single Cell Sequencing Automation

Zymo Research Logo

Zymo Research Launches Research Grant to Empower Mapping the RNome

Magid Haddouchi, PhD, CCO

Cytosurge Appoints Magid Haddouchi as Chief Commercial Officer