Articles by Dennis Curran

C2-symmetric tetrahydrobis(oxazoles) are related to a class of chiral semicorrin ligands and show great promise as ligands for formation of chiral catalysts. Copper complexes of methylene-bridged bis(oxazoles) are highly efficient catalysts for enantioselective cyclopropanations, iridium complexes of directly linked bis(oxazoles) are enantioselective catalysts for transfer hydrogenations, and palladium complexes of the directly linked ligands catalyze asymmetric allylic alkylations. D. Muller,

Department of Chemistry University of Pittsburgh Pittsburgh, PA Organic chemistry in crisis? "Not so," says Dieter Seebach, who argues that the fantastic progress made in this field over the last decade is not a sign of maturation, but instead is only a window opening wider on ever-expanding opportunities. D. Seebach, "Organic synthesis--where now?" Angewandte Chemie, International Edition in English, 29, 1320-67, November 1990. (ETH-Zentrum, Zurich) Measurements in the picosecond realm a

DENNIS P. CURRAN Department of Chemistry University of Pittsburgh Pittsburgh, Pa. Like its natural predecessors FK506 and rapamycin, a non-natural immunophilin ligand (506BD) is a potent inhibitor of the FK506 binding protein's rotomase activity. However, unlike the natural compounds, the nonnatural analog does not interfere with T cell activation. Thus, inhibition of rotamase activity is an insufficient requirement for immunosuppressant action. B.E. Bierer, P.K. Somers, T.J. Wandless, S.J. B

Department of Chemistry University of Pittsburgh Pittsburgh, Pa. Hindered organoaluminum Lewis acids are able to distinguish between structurally similar ethers based on small differences in the size of the ether substituents. Complexation chromatography allows the efficient separation of a mixture of two very closely related ethers based on their differing affinities for a supported aluminum complex. K. Maruoka, S. Nagahara, H. Yamamoto, "Molecular recognition of ethers with modified organoa