Articles by Jim Kling

Data derived from the Science Watch/Hot Papers database and the Web of Science (ISI, Philadelphia) show that Hot Papers are cited 50 to 100 times more often than the average paper of the same type and age. D.G. Burbee et al., "Epigenetic inactivation of RASSF1A in lung and breast cancer and malignant phenotype suppression," J Natl Cancer Inst, 93:691-9, May 2, 2001. (Cited in 105 papers) M. Esteller et al., "A gene hypermethylation profile of human cancer," Cancer Res, 61:3225-9, April 15, 200

Data derived from the Science Watch/Hot Papers database and the Web of Science (ISI, Philadelphia) show that Hot Papers are cited 50 to 100 times more often than the average paper of the same type and age. K.A. Jackson et al., "Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells," J Clin Invest,107:1395-1402, June 2001. (Cited in 122 papers) A.A. Kocher et al., "Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiom

Courtesy of Steve Kay Data derived from the Science Watch/Hot Papers database and the Web of Science (ISI, Philadelphia) show that Hot Papers are cited 50 to 100 times more often than the average paper of the same type and age. P. Schenk et al., "Coordinated plant defense responses in Arabidopsis revealed by microarray analysis," Proc Natl Acad Sci, 97:11655-60, 2000. (Cited in 118 papers) S. Harmer et al., "Orchestrated transcription of key pathways in Arabidopsis by the circadian clock," S

Data derived from the Science Watch/Hot Papers database and the Web of Science (ISI, Philadelphia) show that Hot Papers are cited 50 to 100 times more often than the average paper of the same type and age. M. Adams et al., "The genome sequence of Drosophila melanogaster," Science, 287:2185-95, March 24, 2000. (Cited in 711 papers) G.M. Rubin et al., "Comparative genomics of the eurkaryotes," Science, 287:2204-15. (Cited in 333 papers)  In 1999, Celera Genomics Group wanted to complete

Image: Courtesy of Stephen B. Liggett UN-BALANCING ACT: The figure depicts linkage disequilibrium between ß2-AR SNPS. Genotypes from Caucasians were determined at 13 loci and the degree of linkage disequilibrium between SNPs was calculated. The site at -406 was monomorphic in the Caucasian sample. The promise of pharmacogenetics will not be realized easily. To date, most studies have focused on individual SNPs (single nucleotide polymorphisms), or perhaps a few, but none have consi

Image: ©1999-2002 Elsevier Science  TESTING THE PUDDING: Using clustering of gene expression profiles, researchers showed that yer083c maybe implicated in cell wall biosynthesis. Direct testing of that hypothesis verified this connection. (Reprinted with permission Cell, 102:109-26, 2000.) As genomics morphs into proteomics and the quest to understand the biological functions of proteins accelerates, researchers continue to look for the best methods that will speed their understandi

New NIH policy streamlines grant procedure for animal research.

A new facility should increase The Institute for Genomic Research's sequencing capacity and lower costs.

Data derived from the Science Watch/Hot Papers database and the Web of Science (ISI, Philadelphia) show that Hot Papers are cited 50 to 100 times more often than the average paper of the same type and age. Despite the plethora of microbial genome papers, most do little more than catalog genes and analyze results, says Hervé Tettelin, a microbial genomics investigator at the Institute for Genomic Research, Rockville, Md. They normally are presented, he says, as underpinnings for further

Data derived from the Science Watch/Hot Papers database and the Web of Science (ISI, Philadelphia) show that Hot Papers are cited 50 to 100 times more often than the average paper of the same type and age. Pseudomonas aeruginosa gets around. The bacterium thrives in soil and marshes, on marine coasts, and in plant and animal tissues. Of particular interest is its occasional, but often devastating, inhabitation of the human environment. It is an important cause of bacteremia associated with bur

Volume 16 | Issue 13 | 36 | Jun. 24, 2002 Previous | Next USPS, Biotech Forge Alliance Companies vie for lucrative pathogen-detection system contracts | By Jim Kling Photo Image Graphic Courtesy of SILENT SENTINEL: Cepheid's Gene- Xpert system, core of a developmental bio-hazard detection system intended for use in postal processing facilities. In its ongoing efforts to ensure the safety

Data derived from the Science Watch/Hot Papers database and the Web of Science (ISI, Philadelphia) show that Hot Papers are cited 50 to 100 times more often than the average paper of the same type and age. The hunt for endogenous or synthetic molecules that can stimulate growth hormone production has always been appealing. Finding the right molecule or molecules that control appetite, for example, could have significant financial returns. About two years ago, two research groups, whose work has

Reading genomes is a messy business. Even the terminology—like "shotgun"—evokes images of inelegant science. But Woburn, Mass.-based US Genomics plans to change that. Inventor Eugene Chan based the GeneEngine™ on the same mechanisms cells use to read DNA. He designed a system in which DNA is first linearized and then threaded through a nanofluidic chip at high speeds. Before the analysis, the DNA sample is treated with a set of fluorescently labeled tetramers that cover the thr

Genomics is slowly but surely moving off center stage, replaced by proteomics. Though proteomics is a young field that hasn't fully found its stride, two new developments provide glimpses of the future. At the end of February, attendees of the Cambridge Healthtech Institute (CHI) Genome Tri-Conference 2002 in Santa Clara, Calif., got their first glimpse of the Protein Atlas of the Human Genome™. Developed by Abingdon, UK-based Confirmant Ltd.—a joint venture of Abingdon, UK-based Ox

See related Techlink, "The Data Analysis Grand Prix". For this article, Jim Kling interviewed Patrick O. Brown, Howard Hughes Medical Institute investigator and professor in the department of biochemistry, Stanford University Medical School in Stanford, Calif., and John N. Weinstein, senior investigator at the National Cancer Institute and head of the genomics and bioinformatics group, in Bethesda, Md. Data from the Web of Science show that Hot Papers are cited 50 to 100 times more often than t