Data derived from the Science Watch/Hot Papers database and the Web of Science (ISI, Philadelphia) show that Hot Papers are cited 50 to 100 times more often than the average paper of the same type and age.

Pseudomonas aeruginosa gets around. The bacterium thrives in soil and marshes, on marine coasts, and in plant and animal tissues. Of particular interest is its occasional, but often devastating, inhabitation of the human environment. It is an important cause of bacteremia associated with burn wounds and with hospital-acquired pneumonia in patients on respirators. It is the microbe that most commonly infects the lungs of patients with cystic fibrosis.

Aside from its adaptability, P. aeruginosa is also famous for its natural drug resistance. In general, relatively high doses of aminoglycosides, such as tobramycin, extended-spectrum beta-lactams, and ciprofloxacin, are required to eradicate this organism. P. aeruginosa's genome is one of the largest and most...

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