Articles by William Loomis

LIFE SCIENCES >BY WILLIAM F. LOOMIS Department of Biology University of California, San Diego La Jolla, Calif. "Gene therapy of certain cancers has come a step closer. Neoplasia of retinoblastoma and osteosarcoma cells was suppressed by introducing a functional copy of the RB gene on a retrovirus vector. Unlike the original cell lines, the suppressed cells failed to form tumors when injected into nude mice. H.-J. Huang, J.-K. Yen, J.-Y. Shew, P.-L. Chen, et al, “Suppression of the neop

LIFE SCIENCES BY WILLIAM P. LOOMIS Department of Biology University of California, San Diego La Jolla, Calif. " Bidirectional replication of circular chromosomes in Eseherichia coil stops at orientation-dependent sequences. A protein, tus, recognizes these 21-23 base pair terminators. T. Hill, A. Pelletier, M. Tecklenburg, P. Kuempel, “Identification of the DNA sequence from theE. coil terminus region that halts replication forks,” Cell, 55 (3), 459-66,4 November 1988. M. Hidaka

LIFE SCIENCES WILLIAM F. LOOMISIS Department of Biology University of California, SAN Diego La Jolla, Calif. " The gene coding for the chemoattractant receptor of Diet Dictyostellium amoebae has been isolated, characterized, and inactivated by antisense RNA The predicted protein product is similar to adrenergic and acetylcholine receptors as well as bovine rhodopsin suggesting that G protein-linked receptors evolved from a common progenitor before the appearance of metazoans. P.S. Klein, L

BY WILLIAM F. LOOMIS Department of Biology University of California, San Diego La Jolla, Calif. " GAL4, a yeast transcriptional activator, stimulates transcription of genes if it binds nearby, but it squelches genes to which it cannot bind. It appears that high levels of GALA sequester another common transcription factor. G. Gill, M. Ptashne, “Negative effect of the transcriptional activator GAL4,” Nature, 334 (6184), 721-4,25 August 1988. " Dominant mutations that result in loss