>BY WILLIAM F. LOOMIS
Department of Biology
University of California,
San Diego
La Jolla, Calif.
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Gene therapy of certain cancers has come a step closer. Neoplasia of retinoblastoma and osteosarcoma cells was suppressed by introducing a functional copy of the RB gene on a retrovirus vector. Unlike the original cell lines, the suppressed cells failed to form tumors when injected into nude mice.
H.-J. Huang, J.-K. Yen, J.-Y. Shew, P.-L. Chen, et al, “Suppression of the neoplastic phenotype by replacement of the RB gene in human cancer cells,” Science, 242 (4884), 1563-66, 16 December 1988.
"cAMP activates some protein kinases by binding to two sites on regulatory subunits such that they dissociate from the catalytic subunits. However, it turns out that an R^I subunit lacking one of the cAMP sites works almost as well as the complete subunit.
L.D. Saraswat, G.E. Ringheim, J. Bubis, S.S. Taylor, “Deletion mutants as probes for localizing regions of ...
