It can be impossible to identify full virus particles from empty ones based on size or shape alone. The particle's buoyant density can help you to distinguish between otherwise identical populations. An analytical ultracentrifuge (AUC) in your lab can make quick work of particle partitioning. For more details, visit beckman.com/home.
Beckman: Virus Particle Density
How do you tell a full virus particle from an empty one?
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