Biochemistry

T.A. Steitz, "Structural studies of protein-nucleic acid interaction: the sources of sequence-specific binding," Quarterly Reviews of Biophysics, 23:205-80, 1990. Thomas A. Steitz (Howard Hughes Medical Institute, Yale University): "The explosion of information on the structural basis of DNA and RNA recognition by proteins has been made possible in part by the ability of structural biologists to obtain large quantities of normally rare proteins and nucleic acids through cloning and chemical sy


Register for free to listen to this article
Listen with Speechify
0:00
1:00
Share

T.A. Steitz, "Structural studies of protein-nucleic acid interaction: the sources of sequence-specific binding," Quarterly Reviews of Biophysics, 23:205-80, 1990.

Thomas A. Steitz (Howard Hughes Medical Institute, Yale University): "The explosion of information on the structural basis of DNA and RNA recognition by proteins has been made possible in part by the ability of structural biologists to obtain large quantities of normally rare proteins and nucleic acids through cloning and chemical synthesis. Furthermore, major advances in X-ray crystallography and NMR have greatly reduced the time required to determine a structure. This article reviews all of the structural work in this field during the 1980s and discusses the structural principles of protein-nucleic acid interaction that have emerged from these studies. The structures described have become paradigms for many areas of active research in molecular and develop- mental biology, including the regulation of gene expression.

"This review has been widely cited because it ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!
Already a member? Login Here
Image of a woman in a microbiology lab whose hair is caught on fire from a Bunsen burner.
April 1, 2025, Issue 1

Bunsen Burners and Bad Hair Days

Lab safety rules dictate that one must tie back long hair. Rosemarie Hansen learned the hard way when an open flame turned her locks into a lesson.

View this Issue
Faster Fluid Measurements for Formulation Development

Meet Honeybun and Breeze Through Viscometry in Formulation Development

Unchained Labs
Conceptual image of biochemical laboratory sample preparation showing glassware and chemical formulas in the foreground and a scientist holding a pipette in the background.

Taking the Guesswork Out of Quality Control Standards

sartorius logo
An illustration of PFAS bubbles in front of a blue sky with clouds.

PFAS: The Forever Chemicals

sartorius logo
Unlocking the Unattainable in Gene Construction

Unlocking the Unattainable in Gene Construction

dna-script-primarylogo-digital

Products

Atelerix

Atelerix signs exclusive agreement with MineBio to establish distribution channel for non-cryogenic cell preservation solutions in China

Green Cooling

Thermo Scientific™ Centrifuges with GreenCool Technology

Thermo Fisher Logo
Singleron Avatar

Singleron Biotechnologies and Hamilton Bonaduz AG Announce the Launch of Tensor to Advance Single Cell Sequencing Automation

Zymo Research Logo

Zymo Research Launches Research Grant to Empower Mapping the RNome