H. Fukumoto, T. Kayano, J.B. Buse, Y. Edwards, P.F. Pilch, G.I. Bell, S. Seino, "Cloning and characterization of the major insulin-responsive glucose transporter expressed in human skeletal muscle and other insulin-responsive tissues," The Journal of Biological Chemistry, 264, 7776-9, 15 May 1989.
Graeme Bell (University of Chicago): "One of the most important actions of insulin is the stimulation of glucose uptake by muscle and fat cells. Studies from our laboratory (Hot Team, The Scientist, July 23, 1990, page 20) and others had shown that glucose transport in mammalian cells was mediated by a family of structurally related proteins that have distinct patterns of expression. Of these proteins, the glucose transporter isoform expressed in muscle and adipose tissue was of intense scientific and medical interest, since it could be the key to understanding the molecular basis for decreased glucose uptake in diabetes mellitus. It might be because the cDNA cloning and ...
