Bioconjugate Chemistry Links A Number Of Fields

Landmark Papers Although the term "bioconjugate chemistry" was coined relatively recently, researchers increasingly have been exploring the techniques and applications of this field, particularly during the past 10 years. Simply put, bioconjugate chemistry involves the joining through chemical or biological means of two molecules that exhibit different biological activities to form a new compound with specific biochemical properties. As scientists learn more and more about the roles of specific

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The Scientist spoke to Claude F. Meares of the department of biochemistry at the University of California, Davis, and editor of a new journal, Bioconjugate Chemistry (The Scientist, Association Briefs, March 5, 1990, page 9), to ask about recent trends in this wide-ranging field.

The accompanying table lists key articles in bioconjugate chemistry, which were given to The Scientist by Meares. Meares considers these papers landmark studies that opened the door for further research. The papers are ranked by the number of citations each received from its year of publication through 1989. These data were derived from the Philadelphia-based Institute for Scientific Information's Science Citation Index.

The 10 articles, which have appeared in a variety of journals, cover many topics, including conjugates of antibodies, chelating agents, nucleic acids, and liposomes. The authors, who hail from private laboratories, industry, and academia, work in disciplines as varied as the topics. ...

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