Skip to main content

Biotech claims for safer stem cells

A California biotech announced at the Stem Cell Summit in New York City on Tuesday that they have successfully reprogrammed human skin, kidney, and retina cells to a stem-cell-like state without using potentially cancer-causing retroviruses. But experts say their claims are impossible to evaluate since the work has not been peer-reviewed. The company researchers did not say these new cells produced teratomas -- the sign that cells are truly pluripotent. The company, PrimeGen Biotech based in

Written byAndrea Gawrylewski
| 1 min read

Register for free to listen to this article
Listen with Speechify
0:00
1:00
A California biotech announced at the Stem Cell Summit in New York City on Tuesday that they have successfully reprogrammed human skin, kidney, and retina cells to a stem-cell-like state without using potentially cancer-causing retroviruses. But experts say their claims are impossible to evaluate since the work has not been peer-reviewed. The company researchers did not say these new cells produced teratomas -- the sign that cells are truly pluripotent. The company, PrimeGen Biotech based in Irvine, Ca., said it used carbon-based particles coated with DNA coding for the four transcription factors Oct3/4, SOX2, c-Myc, and Klf4, the New Scientist linkurl:reported.;https://www.newscientist.com/article/dn13384-stem-cell-breakthrough-may-reduce-cancer-risk.html These are the same factors Shinya Yamanaka used with retroviruses to reprogram skin cells into stem cell-like cells linkurl:last November.;https://www.the-scientist.com/blog/display/53873/ In a statement regarding Yamanaka's paper, linkurl:Douglas Melton,;https://www.hhmi.org/research/investigators/melton_bio.html stem cell researcher at Harvard University, said that "retroviruses are a real limitation to stem cell reprogramming" because they can disrupt other genes required for normal cell function. PrimeGen said in an accompanying linkurl:press release;https://www.primegenbiotech.com/news/PR014_(2008-02-26).pdf that they are looking for sponsorship and help in developing their cell lines. But some researchers are skeptical about the company's findings. Until the results go through the peer review process they will be hard to evaluate, linkurl:James Thomson,;https://ink.primate.wisc.edu/~thomson/jamie.html at the University of Wisconsin, Madison, whose group also reported reprogrammed stem cells last November, told linkurl:Forbes.;https://www.forbes.com/business/2008/02/27/biotech-research-cells-biz-cx_mh_0227stem.html One independent researcher who has tested the new cells, linkurl:Denis Clegg;https://www.lifesci.ucsb.edu/mcdb/faculty/clegg/index.html at the University of California, Santa Barbra, told Forbes they behave like embryonic stem cells, but expressed surprise at the company's early announcement.
Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member?
Add The Scientist as a preferred source on Google

Add The Scientist as a preferred Google source to see more of our trusted coverage.

Meet the Author

Related articles background image
The Scientist Digest cover September 2026
September 2026

Multiplex Microscopy Becomes Easier with Encoded Antibodies

A new system that enables researchers to uniquely tag monoclonal antibodies for use in microscopy could help simplify complex imaging studies.

View this Issue
Rethinking ALS Biomarkers: From Discovery to Clinical Impact

Rethinking ALS Biomarkers: From Discovery to Clinical Impact

Alamar Biosciences logo
Best Practices for qPCR Assay Design and Optimization

Best Practices for qPCR Assay Design and Optimization

Bio-Rad
Beyond the Basics: Strategies for Single-Cell and Spatial Transcriptomics Analysis

Beyond the Basics: Strategies for Single-Cell and Spatial Transcriptomics Analysis

bioxcell
Scientist reviewing cellular and molecular data on a computer in a laboratory.

Building Translation-Ready Biomarkers with Connected Workflows

Danaher Logo

Products

Closeup image of a multi channel pipette dispensing pink liquid into a 96-well plate.

The ASSIST PLUS pipetting robot for affordable workflow automation

Integra Logo
Single cells in suspension

Rapidly isolate primary cells and make uniform single-cell suspensions with Corning® Cell Strainers

Corning logo
Abstract image representing cell membranes linked together.

CellBrite® Steady Membrane Stain: Cell surface staining built for real-time imaging

Biotium
sino biological logo

Monod Bio Licenses AI-designed Protein Technologies to SignalChem Biotech for Custom Discovery Assays