Skip to main content

Breaking Up Isn't Hard To Do: A cacophony of sonicators, cell bombs, and grinders

Date: November 9, 1998Comparison of Disruptors With names such as cell crushers, grinders, disintegrators, and pulverizers dominating the field, the business of cell disruption is not for the faint of heart. Some of the functions of these machines are so twisted and diabolical that they would make the Marquis de Sade wince. These devices do the dirty work of the research world, ripping and tearing at the fabric of plants and animal tissues with extreme prejudice to both forms of life. Many scie

Written byBrent Johnson
| 12 min read

Register for free to listen to this article
Listen with Speechify
0:00
12:00

Date: November 9, 1998Comparison of Disruptors

With names such as cell crushers, grinders, disintegrators, and pulverizers dominating the field, the business of cell disruption is not for the faint of heart. Some of the functions of these machines are so twisted and diabolical that they would make the Marquis de Sade wince. These devices do the dirty work of the research world, ripping and tearing at the fabric of plants and animal tissues with extreme prejudice to both forms of life. Many scientists turn a blind eye to this unsavory business, leaving such duties to grad students. Behind the secrecy of closed doors, this little-acknowledged aspect of research has gone without comment until now. Finally, these machines and their creators will be revealed.

There are primarily five methods for disrupting and homogenizing cell tissue. The most familiar is the common vertical blender that typically resides in most household kitchens. The ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!
Already a member?
Add The Scientist as a preferred source on Google

Add The Scientist as a preferred Google source to see more of our trusted coverage.

Meet the Author

Related Topics

Published In

Related articles background image
The Scientist Digest cover September 2026
September 2026

Multiplex Microscopy Becomes Easier with Encoded Antibodies

A new system that enables researchers to uniquely tag monoclonal antibodies for use in microscopy could help simplify complex imaging studies.

View this Issue
Essential Genes Are Dominantly Activated by Single Transcription Factors

Essential Genes Are Dominantly Activated by Single Transcription Factors

EpiCypher Logo
Rethinking ALS Biomarkers: From Discovery to Clinical Impact

Rethinking ALS Biomarkers: From Discovery to Clinical Impact

Alamar Biosciences logo
Engineering CAR-Neutrophils In Vivo to Target Glioblastoma

Engineering CAR-Neutrophils In Vivo to Target Glioblastoma

Miltenyi
Best Practices for qPCR Assay Design and Optimization

Best Practices for qPCR Assay Design and Optimization

Bio-Rad

Products

Closeup image of a multi channel pipette dispensing pink liquid into a 96-well plate.

The ASSIST PLUS pipetting robot for affordable workflow automation

Integra Logo
Single cells in suspension

Rapidly isolate primary cells and make uniform single-cell suspensions with Corning® Cell Strainers

Corning logo
Abstract image representing cell membranes linked together.

CellBrite® Steady Membrane Stain: Cell surface staining built for real-time imaging

Biotium
sino biological logo

Monod Bio Licenses AI-designed Protein Technologies to SignalChem Biotech for Custom Discovery Assays