Breaking Up Isn't Hard To Do: A cacophony of sonicators, cell bombs, and grinders

Date: November 9, 1998Comparison of Disruptors With names such as cell crushers, grinders, disintegrators, and pulverizers dominating the field, the business of cell disruption is not for the faint of heart. Some of the functions of these machines are so twisted and diabolical that they would make the Marquis de Sade wince. These devices do the dirty work of the research world, ripping and tearing at the fabric of plants and animal tissues with extreme prejudice to both forms of life. Many scie

Written byBrent Johnson
| 12 min read

Register for free to listen to this article
Listen with Speechify
0:00
12:00
Share

Date: November 9, 1998Comparison of Disruptors

With names such as cell crushers, grinders, disintegrators, and pulverizers dominating the field, the business of cell disruption is not for the faint of heart. Some of the functions of these machines are so twisted and diabolical that they would make the Marquis de Sade wince. These devices do the dirty work of the research world, ripping and tearing at the fabric of plants and animal tissues with extreme prejudice to both forms of life. Many scientists turn a blind eye to this unsavory business, leaving such duties to grad students. Behind the secrecy of closed doors, this little-acknowledged aspect of research has gone without comment until now. Finally, these machines and their creators will be revealed.

There are primarily five methods for disrupting and homogenizing cell tissue. The most familiar is the common vertical blender that typically resides in most household kitchens. The ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!
Already a member? Login Here

Related Topics

Meet the Author

Published In

Share
Image of a man in a laboratory looking frustrated with his failed experiment.
February 2026

A Stubborn Gene, a Failed Experiment, and a New Path

When experiments refuse to cooperate, you try again and again. For Rafael Najmanovich, the setbacks ultimately pushed him in a new direction.

View this Issue
Human-Relevant In Vitro Models Enable Predictive Drug Discovery

Advancing Drug Discovery with Complex Human In Vitro Models

Stemcell Technologies
Redefining Immunology Through Advanced Technologies

Redefining Immunology Through Advanced Technologies

Ensuring Regulatory Compliance in AAV Manufacturing with Analytical Ultracentrifugation

Ensuring Regulatory Compliance in AAV Manufacturing with Analytical Ultracentrifugation

Beckman Coulter logo
Conceptual multicolored vector image of cancer research, depicting various biomedical approaches to cancer therapy

Maximizing Cancer Research Model Systems

bioxcell

Products

Sino Biological Logo

Sino Biological Pioneers Life Sciences Innovation with High-Quality Bioreagents on Inside Business Today with Bill and Guiliana Rancic

Sino Biological Logo

Sino Biological Expands Research Reagent Portfolio to Support Global Nipah Virus Vaccine and Diagnostic Development

Beckman Coulter

Beckman Coulter Life Sciences Partners with Automata to Accelerate AI-Ready Laboratory Automation

Refeyn logo

Refeyn named in the Sunday Times 100 Tech list of the UK’s fastest-growing technology companies