Brrrr-ying the Results

Holding laboratory mice at temperatures lower than those the animals prefer could be altering their physiology and skewing experimental results.

Written byBob Grant
| 5 min read

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ANDRZEJ KRAUZE

A few years ago, tumor immunologist Elizabeth Repasky realized that she had heard from too many oncologists, colleagues, and friends that cancer patients regularly reported feeling cold and unable to regulate their internal thermometers. At her lab at the Roswell Park Cancer Institute in Buffalo, New York, she decided to build on her experience studying thermal physiology and immunology to see exactly what might be going on with regard to temperature and cancer. “I’ve always gone around telling people it’s really important to be warm,” she says. “Being warm is a really important part of dealing with diseases like cancer.”

Laboratory mice are routinely held at temperatures well below what’s called their “thermoneutral zone,” or the temperature range in which their metabolism functions most efficiently, ...

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Meet the Author

  • From 2017 to 2022, Bob Grant was Editor in Chief of The Scientist, where he started in 2007 as a Staff Writer. Before joining the team, he worked as a reporter at Audubon and earned a master’s degree in science journalism from New York University. In his previous life, he pursued a career in science, getting a bachelor’s degree in wildlife biology from Montana State University and a master’s degree in marine biology from the College of Charleston in South Carolina. Bob edited Reading Frames and other sections of the magazine.

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