Building Oligos Graphically

For many researchers, the process of acquiring custom oligonucleotides has never been more challenging. There are simply too many choices. For example, the increasing variety of specialty oligos, used in tasks ranging from diagnostics to sequencing, can make ordering a grueling and time-consuming task. And with a pool of more than 200 suppliers worldwide, choosing the right company for the job can be equally daunting. To help scientists obtain the best oligo for the task at hand, Seattle-based D

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The company collaborates with a select group of vendors, known as the Synthesis Network, each with a specialty such as high-volume primers or oligos with modifications such as internal tags or labels. "We've carefully looked at the suppliers out there and chosen those who are the best at what they do," says company spokesman David Hensel, adding that as techniques advance, new suppliers will be added to supply them. Once OligoEngine receives an order, the system automatically determines which of its partner suppliers would be best suited to synthesize the oligos and processes the request.

The most distinctive feature of OligoEngine is its interface, an interactive menu-based system that allows researchers to type or paste in sequences, seeing a visual representation as they go. The user can use pull-down menus to define specific parameters such as chimeric alterations and internal modifications, eliminating the need for familiarity with each supplier's unique ...

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