Simple dinucleotide repeats are commonly found throughout the human genome, but their functional significance has been unclear. In an Advanced Online Publication in Nature Structural Biology, Jingyi Hui and colleagues describe an unusual role for a CA-repeat in regulating mRNA splicing (Nature Structural Biology, doi:10.1038/nsb875, 25 November 2002).The human endothelial nitric oxide synthase (eNOS) gene contains a polymorphic CA repeat, (CA)14-44, in intron 13 that has been linked to a risk fo
Simple dinucleotide repeats are commonly found throughout the human genome, but their functional significance has been unclear. In an Advanced Online Publication in
The human endothelial nitric oxide synthase (
These results suggest that CA repeats and hnRNP L may regulate the splicing of other genes containing intronic polymorphic repeats.
The liquid world of fetal development provides a rich source of nutrition and protection tailored to meet the needs of the growing fetus.
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