Caliber I.D. Debuts the RS-G4, A New Class of Confocal Microscope

Fusing extraordinary speed with miltiple wavelengths for very large area imaging

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Caliber I.D. launches the RS-G4, a new class of modular confocal microscope that delivers confocal’s expected high resolution and clean contrast while overcoming its limited scan areas. Scanning large areas at lightning fast speeds, RS-G4 dramatically cuts the time required for efficient study of next-generation large format samples including brain slices, plant cross-sections, or large fields of cells or tissue critical for high-throughput screening.

Consider the attached image of a whole mouse brain (Figure 1). The RS-G4 scanned and stitched 1050 fields to image this 12mm x 8mm area (approximately 0.5” x 0.25”) in just 270 seconds (4.5 minutes), approximately one-tenth the time required by other currently-available systems. Yet, as demonstrated by the inset, the image retains all the confocal detail and resolution offered by the 40x/1.30NA oil immersion objective.

The cornerstone of RS-G4’s innovative performance is its high-speed strip mosaic imaging. On the hardware side, continual stage movement is ...

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