Caliber I.D. Debuts the RS-G4, A New Class of Confocal Microscope

Fusing extraordinary speed with miltiple wavelengths for very large area imaging

Written byCaliber Imaging and Diagnostics, Inc.
| 2 min read

Register for free to listen to this article
Listen with Speechify
0:00
2:00
Share

Caliber I.D. launches the RS-G4, a new class of modular confocal microscope that delivers confocal’s expected high resolution and clean contrast while overcoming its limited scan areas. Scanning large areas at lightning fast speeds, RS-G4 dramatically cuts the time required for efficient study of next-generation large format samples including brain slices, plant cross-sections, or large fields of cells or tissue critical for high-throughput screening.

Consider the attached image of a whole mouse brain (Figure 1). The RS-G4 scanned and stitched 1050 fields to image this 12mm x 8mm area (approximately 0.5” x 0.25”) in just 270 seconds (4.5 minutes), approximately one-tenth the time required by other currently-available systems. Yet, as demonstrated by the inset, the image retains all the confocal detail and resolution offered by the 40x/1.30NA oil immersion objective.

The cornerstone of RS-G4’s innovative performance is its high-speed strip mosaic imaging. On the hardware side, continual stage movement is ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member? Login Here
Share
July Digest 2025
July 2025, Issue 1

What Causes an Earworm?

Memory-enhancing neural networks may also drive involuntary musical loops in the brain.

View this Issue
Accelerating Recombinase Reprogramming with Machine Learning

Accelerating Recombinase Reprogramming with Machine Learning

Genome Modeling and Design: From the Molecular to Genome Scale

Genome Modeling and Design: From the Molecular to Genome Scale

Twist Bio 
Screening 3D Brain Cell Cultures for Drug Discovery

Screening 3D Brain Cell Cultures for Drug Discovery

DNA and pills, conceptual illustration of the relationship between genetics and therapeutic development

Multiplexing PCR Technologies for Biopharmaceutical Research

Thermo Fisher Logo

Products

waters-logo

Waters and BD's Biosciences & Diagnostic Solutions Business to Combine, Creating a Life Science and Diagnostics Leader Focused on Regulated, High-Volume Testing

zymo-research-logo

Zymo Research Partners with Harvard University to Bring the BioFestival to Cambridge, Empowering World-class Research

10x-genomics-logo

10x Genomics and A*STAR Genome Institute of Singapore Launch TISHUMAP Study to Advance AI-Driven Drug Target Discovery

The Scientist Placeholder Image

Sino Biological Sets New Industry Standard with ProPure Endotoxin-Free Proteins made in the USA