Cancer Genetics

Edited by Steven Benowitz R.A. Steinman, B. Hoffman, A. Iro, C. Guillouf, D.A. Liebermann, M.E. Elhouseini, "Induction of p21 (WAF1/CIP1) during differentiation," Oncogene, 9:3389-96, 1994. (Cited in more than 40 publications as of February 1996) Comments by Richard A. Steinman, University of Pittsburgh Cancer Institute. CELL CYCLIST: Richard Steinman's cell differentiation research may provide clues to cancer development Richard A. Steinman, an assistant professor of medicine at the Unive

Written bySteven Benowitz

| 2 min read

Save for Later

Listen with Speechify

0:00

2:00

Edited by Steven Benowitz
R.A. Steinman, B. Hoffman, A. Iro, C. Guillouf, D.A. Liebermann, M.E. Elhouseini, "Induction of p21 (WAF1/CIP1) during differentiation," Oncogene, 9:3389-96, 1994. (Cited in more than 40 publications as of February 1996)

Comments by Richard A. Steinman, University of Pittsburgh Cancer Institute.

CELL CYCLIST: Richard Steinman's cell differentiation research may provide clues to cancer development

Richard A. Steinman, an assistant professor of medicine at the University of Pittsburgh Cancer Institute, and his collaborators at Temple University in Philadelphia show in this article that a protein, p21(WAF1), plays a key role in triggering cell differentiation.

Other scientists previously had found that the p21 protein stalls cell division in the early G1 phase of the cell's cycle in response to DNA damage. The effect was controlled by p53, a well-documented tumor-suppressor gene that was thought to activate p21(WAF1) in damaged cells, giving them time to repair DNA damage before ...

Interested in reading more?

Become a Member of

Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!

Join for free today

Already a member? Login Here