Johansson et al. expressed human CD46 in transgenic mice and subsequently exposed them to N. meningitidis. They observed that human CD46 transgenic mice were susceptible to meningococcal disease because bacteria could cross the blood–brain barrier in these animals. In addition, they showed that development of disease was more efficient with piliated bacteria after intranasal—but not intraperitoneal—challenge of ...
CD46 facilitates meningitis
Expression of human CD46 renders mice susceptible to meningococcal disease

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