Edited by: Steven Benowitz

REGULATED ACTIVITY: Vanderbilt’s John Exton describes the enzyme phospholipase D’s involvement in the signaling pathway of RhoA.
K.C. Malcolm, A.H. Ross, R-G. Qui, M. Symons, J.H. Exton, "Activation of rat liver phospholipase D by the small GTP-binding protein RhoA," Journal of Biological Chemistry, 269:25951-4, 1994. (Cited in nearly 80 publications through October 1996) Comments by John H. Exton, Howard Hughes Medical Institute, Vanderbilt University School of Medicine, Nashville, Tenn.

The enzyme phosholipase D is seemingly everywhere, cellularly speaking, in living systems. Yet scientists aren't completely sure about its precise function. In this paper, the authors describe the enzyme's involvement in the signaling pathway of an important cellular protein, RhoA.

"The enzyme's activity is turned on by hormones, neurotransmitters, and growth factors in mammalian systems," says John H. Exton, a Howard Hughes Medical Institute investigator and a professor of molecular physiology and biophysics at the...

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