Cell Biology

R. SchUle, P. Rangarajan, S. Kliewer, L.J. Ransone, et al., "Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor," Cell, 62:1217-26, 1990. Roland SchUle (Howard Hughes Medical Institute, The Salk Institute, La Jolla, Calif.): "The molecular mechanisms by which hormone receptors inhibit cellular proliferation and by which growth factors stimulate this process are poorly understood. In addressing this issue, we have shown that the proto-oncogene Jun/AP-1 can function a

| 1 min read

Register for free to listen to this article
Listen with Speechify
0:00
1:00
Share

R. SchUle, P. Rangarajan, S. Kliewer, L.J. Ransone, et al., "Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor," Cell, 62:1217-26, 1990.

Roland SchUle (Howard Hughes Medical Institute, The Salk Institute, La Jolla, Calif.): "The molecular mechanisms by which hormone receptors inhibit cellular proliferation and by which growth factors stimulate this process are poorly understood. In addressing this issue, we have shown that the proto-oncogene Jun/AP-1 can function as a potent regulator of the hormone-activated glucocorticoid receptors.

"Furthermore, we have demonstrated that treatment of cells with glucocorticoids leads to a potent inhibition of AP-1 stimulated transcription. GR-mediated repression is observed when the AP-1 site is activated by endogenous levels of Jun/AP-1, transfection of c-Jun expression plasmids, or increasing AP-1 activity by TPA treatment. The process through which AP-1 and the nuclear receptors modulate each other's activities is referred to as cross-coupling.

"Our paper has had a significant impact on this ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!
Already a member? Login Here
July Digest 2025
July 2025, Issue 1

What Causes an Earworm?

Memory-enhancing neural networks may also drive involuntary musical loops in the brain.

View this Issue
Genome Modeling and Design: From the Molecular to Genome Scale

Genome Modeling and Design: From the Molecular to Genome Scale

Twist Bio 
Screening 3D Brain Cell Cultures for Drug Discovery

Screening 3D Brain Cell Cultures for Drug Discovery

Discover how to streamline tumor-infiltrating lymphocyte production.

Producing Tumor-infiltrating Lymphocyte Therapeutics

cytiva logo
Explore synthetic DNA’s many applications in cancer research

Weaving the Fabric of Cancer Research with Synthetic DNA

Twist Bio 

Products

The Scientist Placeholder Image

Sino Biological Sets New Industry Standard with ProPure Endotoxin-Free Proteins made in the USA

sartorius-logo

Introducing the iQue 5 HTS Platform: Empowering Scientists  with Unbeatable Speed and Flexibility for High Throughput Screening by Cytometry

parse_logo

Vanderbilt Selects Parse Biosciences GigaLab to Generate Atlas of Early Neutralizing Antibodies to Measles, Mumps, and Rubella

shiftbioscience

Shift Bioscience proposes improved ranking system for virtual cell models to accelerate gene target discovery