Cell Death

Edited by: Thomas W. Durso
H. Hsu, J. Xiong, D.V. Goeddel, "The TNF receptor 1-associated protein TRADD signals cell death and NF-b activation," Cell, 81:495-504, 1995. (Cited in more than 150 publications as of April 1997)

Comments by Hailing Hsu, Amgen Inc., Thousand Oaks, Calif.

Tumor necrosis factor (TNF) is an immunoregulatory cytokine whose activities are signaled main through a cell surface receptor called TNF receptor 1 (TNFR1). Abnormal regulation of TNF has been implicated in inflammatory diseases, such as rheumatoid arthritis.

In this paper, a team of researchers from Tularik Inc., a biotechnology company in South San Francisco, Calif., examined how TNFR1 regulates TNF activities. Hailing Hsu then was a postdoc at Tularik and currently is a research scientist at Amgen Inc. of Thousand Oaks, Calif. She says that TNF, upon binding to TNFR1 on the cell surface, engages in cell death and activation of NF-b, a...