Channel Candidates

By Kerry Grens

While many potential mechanotransduction channels have been disregarded outright, a few have proved promising and others still remain a possibility. here are a few of the likeliest candidates, past and present. Those that remain a possibility are marked with an asterisk (*).

Nompc, transient receptor potential (TRP) channel in Drosophila Mutants have vestibular defects and altered transduction current NompC gene is not present in mammals Science, 287:2229-34, 2000
TRPA1, mammalian TRP channel Antibody to channel localizes to stereocilia tips, and inhibition of the channel alters transduction current Knockout mice have no hearing disabilities Nature, 432:723-30, 2004
ENaC, family of amiloridesensitive epithelial sodium channels C. elegans mutants are defective for mechanosensation; protein localized to hair cell stereocilia; also present in sensory endings in skin Conductance too low; knockout mice have normal hearing J Physiol-London, 558:659-69, 2004

Interested in reading more?

Magaizne Cover

Become a Member of

Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!
Already a member?