November 2007

Since beginning his career as an engineer for Douglas Aircraft, Frederick Sachs has been a research fellow at NIH's biophysics laboratory, and served as both an NIH physiology reviewer and NSF consultant. His most recent work, as professor of physiology and biophysics at the University of Buffalo, pinpointed a protein in tarantula venom as a potential drug candidate to treat atrial fibrillation. In a provocative Opinion, Sachs proffers that funneling more money into the NIH budget ha

How far has open access come in a decade? And where will it go in the next?

Fixing authorship In his column "Me first!" Glenn McGee proposes two changes to fix the system of scientific authorship.1 Drawing simple authorship rules is easy when a paper requires a single field of expertise and can be understood by all authors. However, many papers require that people from different fields come together, and not all authors will understand all the aspects of the paper, even if they devised part of the strategy. How can rules deal with that? Disputes aris

Related Articles A Channel at Large The Inner Workings of Hearing Machinery Cracking Open a New Channel Family Channel Candidates Facelessness, faced The singing ear Alzheimer's: Type 3 Diabetes? Model of insulin's influence on amyloid β Opening Potassium Channels to Scrutiny Manna from hell Birth of a plant Clerkship in Croatia Buzzing for bombs Slideshow: A mysterious kidney disease Unlocking one of many nondescript doors in a long hallway at the Croatian Institute for Brain

Related Articles A Channel at Large The Inner Workings of Hearing Machinery Cracking Open a New Channel Family Channel Candidates The singing ear Baby brain bank Alzheimer's: Type 3 Diabetes? Model of insulin's influence on amyloid β Opening Potassium Channels to Scrutiny After giving a lecture in Windsor, England last February, neuroscientist Bradley Duchaine was approached by a man who'd been in the audience. He told Duchaine, professor at the Institute of Cognitive Neuroscienc

Related Articles A Channel at Large The Inner Workings of Hearing Machinery Cracking Open a New Channel Family Channel Candidates Facelessness, faced Baby brain bank Alzheimer's: Type 3 Diabetes? Model of insulin's influence on amyloid β Opening Potassium Channels to Scrutiny About 16 years ago, Ralph Harvey, an anesthesiology professor at the University of Tennessee's College of Veterinary Medicine, walked into an examination room where a small, white poodle sat atop an examinat

Related Articles Manna from hell Birth of a plant Clerkship in Croatia Baby brain bank Slideshow: A mysterious kidney disease From ten meters away, the sound of a million honeybees is surprisingly soothing, like treetops whooshing in the breeze. At a daring six meters, the droning becomes ominous and insistent. At two meters away, the humming is so malevolent that the sky seems to darken. "Beautiful music, yes?" says Nikola Kezić, as if there is no doubt. Arranging folding ch

The already-endangered Atelopus zeteki (Panamanian Golden Frog) is now facing extermination from the Bd fungus." />The already-endangered Atelopus zeteki (Panamanian Golden Frog) is now facing extermination from the Bd fungus. While working on her PhD in 1992, Karen Lips went to Las Tablas, Panama, to study the biology of a tree frog, Hyla calypso, an inch-long, spiny, bright-green creature. As she walked through transects in the forest, measuring and sexing frog individuals, here and

Credit: © THOM GRAVES" /> Credit: © THOM GRAVES FOCUS ON NEUROSCIENCE >> In "A Channel At Large," Kerry Grens explores why the identity of an ion channel in the inner ear has eluded scientists for decades. That's just one of several neuroscience-related pieces in this issue, which you may very well be reading at the Society for Neuroscience's annual meeting in San Diego, from November 3-7. Also see "Facelessness, faced," "The singing ear," and "Alzheimer's: Type

A Channel at Large What is the mechanotransduction channel in hearing that has evaded scientists for decades? 

The Inner Workings of Hearing Machinery var FO = { movie:"http://www.the-scientist.com/supplementary/flash/53808/infographic.swf", width:"520", height:"580", majorversion:"8", build:"0", xi:"true"}; UFO.create(FO, "ufoDemo"); Please download the Adobe Flash Player to view this content: Related Articles A Channel at Large Cracking Open a New Channel Family Channel Candidates Baby brain bank Facelessness

Cracking Open a New Channel Family Michael CahalanCourtesy of Karinne Cahalan What lessons can hearing-channel researchers learn from a similar but ultimately successful search? By Kerry Grens Related Articles 1-3 Orai is a four-transmembrane protein with high calcium selectivity that interacts with a calcium sensor called Stim to mediate calcium influx. CRAC bears "no channel homology, obviously, [and] no classical pore sequence,

Channel Candidates By Kerry Grens While many potential mechanotransduction channels have been disregarded outright, a few have proved promising and others still remain a possibility. here are a few of the likeliest candidates, past and present. Those that remain a possibility are marked with an asterisk (*). CHANNEL EVIDENCE FOR EVIDENCE AGAINST REFERENCES Nompc, transient receptor potential (TRP) channel in Drosophila

Manna from hell Photographs by Mirko Beović/ 1 "This so-called Chinese-herb nephropathy is characterized by a pattern of interstitial fibrosis similar to that of Balkan endemic nephropathy," the authors wrote. Pavo Lukšić (above) and his horse (below) in front of his uncle's house. Grollman, a pharmacologist who has pushed for stricter regulation of herbal supplements, says he immediately phoned a Croatian colleague. Grollman was soon on a plane

Clerkship in Croatia A coincidence sent a second-year medical student to the Croatian countryside to survey farmers, and led her to an important hypothesis about food contamination. By Julia C. Mead Related Articles 1 Every other year or so, except when the war intervened, health investigators visit a cluster of endemic villages to track the numbers of endemic nephropathy deaths and diagnoses and to screen for warning signs of the disease. Bearing a lengthy qu

var FO = { movie:"http://www.the-scientist.com/supplementary/flash/53785/53785.swf", width:"505", height:"500", majorversion:"8", build:"0", xi:"true"}; UFO.create(FO, "ufoDemo"); A mysterious kidney disease Julia Mead traveled to Croatia to learn how an international team of scientists confirmed that poisoned bread causes a kidney disease endemic to the Balkans and verified that the same toxic ingredient was in herbal supplements used around the world. Photographs

Birth of a plant Aristolochia's place in pharmacopeias worldwide By Julia C. Mead Related Articles 1 Practitioners in India, Japan, and Sudan use Aristolochia plants, too. The United States and a few other countries now ban the import of those supplements, but seeds, roots, and supplements are available over the Internet. Every single part of the plant - the leaves, roots, seeds, and stalks - and every Aristolochia species is poisonous. References

Open Access 2.0 © Grant Faint/Getty Images The nautilus: where - and how - OA will actually work By Joseph J. Esposito Related Articles The nautilus model of scientific publishing OA, OK? The debate over open access to the scientific literature appears to be moving onto a new phase. Many continue to argue one side or the other of a binary choice: Either all research publishing should be open access, or only traditional publishing can maintain

The nautilus model of scientific publishingClick on image to view at full size Related Articles Open Access 2.0 OA, OK?

var FO = { movie:"/supplementary/html/52903/Charts/FC_2_3_Pie2D.swf", width:"520", height:"450", majorversion:"8", build:"0", xi:"true", flashvars:"&dataURL=/supplementary/xml/53804/institution.xml&chartWidth=520&chartHeight=450" }; UFO.create(FO, "citizenship");Respondents' Type of Institution Half of this year's respondents work in the university setting, with researchers in medical schools making up 21% of respondents. Replacement content Rollover graph f

First-Timers By Kirsten Weir Related Articles Best Places to Work in Academia, 2007 Easy livin' at Dalhousie Massachusetts General Hospital: View from the top Purdue pushes forward Survey Methodology Ranking Tables Top 15 US Academic Institutions Top 10 International Academic Institutions Top 40 US Academic Institutions Best Countries for Academic Research Best Places to Work: Survey Findings PDF

Best countries for Academic Research This year Belgium ranked top country to do academic research, for the first time in the survey's history. In another first, Brazil and Mexico debuted on the best countries chart at 11 and 14th place respectively Use the interactive chart below to sort the top ranked institutions by category. Resize the rows or scroll within the chart to view category. Click here to view the printable PDF. // create ActiveWidgets data model - CSV text table

Top 10 International Academic Institutions Use the interactive chart below to sort the top ranked institutions by category. Resize the rows or scroll within the chart to view category. Click here to view the printable PDF. // create ActiveWidgets data model - CSV text table var table = new AW.CSV.Table; // provide data URL - plain text comma-separated file table.setURL("/supplementary/csv/53794/top10_internat.csv"); // start asyncronous data retrieval table.reques

The Top 15 US Academic Institutions Use the interactive chart below to sort the top ranked institutions by category. Resize the rows or scroll within the chart to view category. Click here to view the printable PDF. // create ActiveWidgets data model - CSV text table var table = new AW.CSV.Table; // provide data URL - plain text comma-separated file table.setURL("/supplementary/csv/53794/top15.csv"); // start asyncronous data retrieval table.request(); // defi

View from the top By Kirsten Weir Related Articles Best Places to Work in Academia, 2007 Easy livin' at Dalhousie First-Timers Purdue pushes forward Survey Methodology Ranking Tables Top 15 US Academic Institutions Top 10 International Academic Institutions Top 40 US Academic Institutions Best Countries for Academic Research Best Places to Work: Survey Findings PDF What makes Massachusetts Gene

Survey Methodology Related Articles Best Places to Work in Academia, 2007 Easy livin' at Dalhousie First-Timers Massachusetts General Hospital: View from the top Purdue pushes forward Ranking Tables Top 15 US Academic Institutions Top 10 International Academic Institutions Top 40 US Academic Institutions Best Countries for Academic Research Best Places to Work: Survey Findings PDF Survey Form: A web

Purdue pushes forward By Andrea Gawrylewski Related Articles Best Places to Work in Academia, 2007 Easy livin' at Dalhousie First-Timers Massachusetts General Hospital: View from the top Survey Methodology Ranking Tables Top 15 US Academic Institutions Top 10 International Academic Institutions Top 40 US Academic Institutions Best Countries for Academic Research Best Places to Work: Survey Findings

By Kerry Grens LITERATUREARTICLE EXTRASRelated ArticleAlzheimer's: Type 3 Diabetes?Channel CandidatesA Channel at LargeThe Inner Workings of Hearing MachineryCracking Open a New Channel FamilyFacelessness, facedThe singing earBaby brain bankOpening Potassium Channels to ScrutinyDownstream of insulin signaling are links to amyloid β (Aβ), the principle peptide that forms the plaqu

By Stephen PincockBIOBUSINESSWhen Klaus Stöhr left the World Health Organization to take a job at the Swiss drug giant Novartis in February, there were some who questioned whether the most prominent figure in the global fight against avian influenza had forsaken public health for profit margins. "I don't see why this should be good news," wrote one blogger with the moniker "gsgs" on a site devoted to pandemic flu soon after t

Slideshow: A Microscopic History The National Museum of Health and Medicine has an extensive collection of microscopes. Here, in text by Adrienne Noe and Michael Rhode of the National Museum of Health and Medicine, and photos by Jason Varney, is a virtual guided tour. var FO = { movie:"http://www.the-scientist.com/supplementary/flash/53973/53973.swf", width:"500", height:"580", majorversion:"8", build:"0"}; UFO.create(FO, "ufoDemo"); Please download the Adobe Flash Player

Jack Szostak's pioneering work has already been rewarded with a Lasker Award. Now he has one more big item on his to-do list: Creating artificial life.

Credit: Courtesy of Piero Carninci" /> Credit: Courtesy of Piero Carninci The paper: The FANTOM Consortium and RIKEN, "The transcriptional landscape of the mammalian genome," Science, 309:1559-63, 2005. (Cited in 251 papers) The finding: Techniques such as cap-analysis gene-expression and gene-identification signature technology allowed a group led by Yoshihide Hayashizaki at the RIKEN Institute in Wako, Japan, to look more in-depth at the mouse tran

Credit: Omikron / Photo Researchers, Inc" /> Credit: Omikron / Photo Researchers, Inc The paper: F.W. Studier, "Protein production by auto-induction in high-density shaking cultures," Protein Express Purif, 41:207-34, 2005. (Cited in 124 papers) The finding: While working on the National Institutes of Health's structural genomics project, William Studier at the Brookhaven National Laboratory devised a method that produced up to 10 times the protein

Credit: Jeremy Burgess / Photo Researchers, Inc" /> Credit: Jeremy Burgess / Photo Researchers, Inc The paper: J. Gans et al., "Computational improvements reveal great bacterial diversity and high metal toxicity in soil," Science, 309:1387-90, 2005. (Cited in 72 papers) The finding: John Dunbar and colleagues at Los Alamos National Laboratory developed a statistical technique to more accurately estimate the diversity of bacteria found in soil. Their reanalysis

Credit: BILL CRAMER / WONDERFUL MACHINE INC." /> Credit: BILL CRAMER / WONDERFUL MACHINE INC. In Jennifer Elisseeff's small tissue-culture room at Johns Hopkins University, she points to an eraser-sized pellet of two-layered hydrogel floating in culture medium. She explains how the cells, encapsulated within juxtaposed layers of gel, exchange signals to help them grow. Knowing what those signals are could help her design a hydrogel that would regenerate diseased tissue. As a teen

Related Articles Going Live How it Works: Two-Photon Microscopy Pooling resources Prioritizing speed Mix and match Deep down view Sticking to the surface Know your needs - "The decision is not wide-field versus confocal," says Watkins. "It's what you're trying to get out of the system." Figuring out the options can easily take a year. Talk to others who have set up similar experiments, and try out as many systems as possible. Or, suggests Maddox, reach out to live-cell microscop

How to choose a live-cell imaging microscope setup from the maze of available options

Related Articles Tips for choosing a microscope setup Going Live How it Works: Two-Photon Microscopy Prioritizing speed Mix and match Deep down view Sticking to the surface User: Lynne Coluccio, a cell biologist at Boston Biomedical Research Institute, Watertown, Mass. Project: Structure and function of the unconventional (nonmuscle) myosin, myo-1c, expressed in the hair cells of the inner ear. Problem: Unless a lab focuses primarily on imaging, few researche

Related Articles Tips for choosing a microscope setup Going Live How it Works: Two-Photon Microscopy Pooling resources Mix and match Deep down view Sticking to the surface User: Peter Robin Hiesinger, a neurogeneticist at UT Southwestern Medical Center in Dallas. Project: Real-time imaging (seconds to minutes) of synaptic transmission at the neuromuscular junction of the developing fly larva; time-lapse imaging (hours to days) of neuronal outgrowth in cultures of dev

Related Articles Tips for choosing a microscope setup Going Live How it Works: Two-Photon Microscopy Pooling resources Prioritizing speed Deep down view Sticking to the surface User: Anna Barsukova, a graduate student in the lab of Michael Forte, a cell biologist at Oregon Health and Science University in Portland. Project: Imaging calcium flux in mitochondria of primary neurons in response to cellular stress, a key apoptotic mechanism in neurodegenerative disease.

Related Articles Tips for choosing a microscope setup Going Live How it Works: Two-Photon Microscopy Pooling resources Prioritizing speed Mix and match Sticking to the surface User: Pascal Steiner, a postdoc in the lab of Harvard University neuroscientist Bernardo Sabatini. Project: Imaging changes in spine morphology over time at the neuronal synapse. Problem: Steiner images in 400-µm hippocampal slices in order to capture the 3D branching complexity of

Related Articles Tips for choosing a microscope setup Going Live How it Works: Two-Photon Microscopy Pooling resources Prioritizing speed Mix and match Deep down view User: Warwick Nesbitt, a hematologist at Monash University in Melbourne, Australia. Project: Quantifying the adhesion footprint of platelets on proteins in the blood vessel cell wall. Problem: Achieving ultrahigh resolution. Solution: Nesbitt uses total internal reflection fluorescen

Related Articles Going Live Tips for choosing a microscope setup Pooling resources Prioritizing speed Mix and match Deep down view Sticking to the surface Two-photon microscopy offers two advantages over other live cell imaging techniques: It penetrates up to 1 mm into tissue and it minimizes phototoxicity because the beam excites just a single focal point at a time. In order to excite a fluorophore labeling the tissue, two long-wavelength, low-energy photons must meet nearly simultan

To create his images, Hooke used elaborately gold-stamped and turned microscopes such as the one pictured.