D.F. Hunt, H. Michel, T.A. Dickinson, J. Sha-banowitz, A.L. Cox, K. Sakaguchi, E. Appella, H.M. Grey, A. Sette, "Peptides presented to the immune system by the murine class II major histocompatibility complex molecule I-Ad," Science, 256:1817-20, 1992.
Donald F. Hunt (Departments of Chemistry and Pathology, University of Virginia, Charlottesville): "A complex mixture containing more than 10,000 peptide fragments derived from cellular proteins is displayed on the cell surface in association with molecules of the major histocompatibility complex (MHC), class I glycoproteins. Cytotoxic T lymphocytes (CTL) bind to class I molecules, sample the peptides being presented, and lyse those cells that display unusual fragments derived from viruses or tumors.
"In a second stage of the immune response, antibodies secreted by B cells bind to and inactivate viral particles dumped into the extracellular medium as a result of cell lysis. Labeled proteins are ingested or endocytosed by macrophage cells that then degrade ...
